Pediatric parenteral amino acid mixture in low birth weight infants

W. C. Heird, W. Hay, Richard Helms, M. C. Storm, S. Kashyap, R. B. Dell

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

A mixture of amino acids designed to maintain normal plasma amino acid concentrations in infants and children requiring parenteral nutrition was evaluated in 28 low birth weight (LBW) infants (birth weight, 750 to 1750 g; postnatal age, 1 to 4 weeks) who required parenteral nutrients for optimal nutritional management. Sixteen babies received only parenteral nutrients for five to 21 days. Ten of these received a typical regimen by peripheral vein (1.91 ± 0.16 g/kg/d of amino acids and 44.7 ± 4.4 kcal/kg/d) and six received a typical regimen through a central vein (2.39 ± 0.11 g/kg/d of amino acids and 95.9 ± 14.5 kcal/kg/d). Mean weight gain of the peripheral vein subgroup was 10.3 ± 10.6 g/kg/d; mean nitrogen balance was 230 ± 66 mg/kg/d. Both the mean rate of weight gain (17.2 ± 5.1 g/kg/d) and the mean rate of nitrogen retention (267 ± 49 g/kg/d) of the central vein subgroup were similar to intrauterine rates. In these two subgroups as well as the total population, plasma concentrations of all amino acids except phenylalanine were within the 95% confidence limits of the plasma concentrations observed in LBW infants fed sufficient amounts of human milk to result in a rate of weight gain similar to the intrauterine rate. However, although plasma tyrosine and cyst(e)ine concentrations were within the 95% confidence limits of the plasma concentrations goals, the LBW infant's ability to use N-acetyl-L-tyrosine and cysteine HCl appears to be even less than that of the term infant and older child. In toto, these data support the efficacy of the amino acid mixture evaluated for LBW infants. Of equal importance, they suggest that the LBW infant's ability to use parenterally delivered amino acids is not as limited as commonly thought.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalPediatrics
Volume81
Issue number1
StatePublished - 1988
Externally publishedYes

Fingerprint

Low Birth Weight Infant
Pediatrics
Amino Acids
Veins
Weight Gain
Nitrogen
Food
Parenteral Nutrition
Acetylcysteine
Human Milk
Phenylalanine
Birth Weight
Tyrosine
Cysts
Population

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Heird, W. C., Hay, W., Helms, R., Storm, M. C., Kashyap, S., & Dell, R. B. (1988). Pediatric parenteral amino acid mixture in low birth weight infants. Pediatrics, 81(1), 41-50.

Pediatric parenteral amino acid mixture in low birth weight infants. / Heird, W. C.; Hay, W.; Helms, Richard; Storm, M. C.; Kashyap, S.; Dell, R. B.

In: Pediatrics, Vol. 81, No. 1, 1988, p. 41-50.

Research output: Contribution to journalArticle

Heird, WC, Hay, W, Helms, R, Storm, MC, Kashyap, S & Dell, RB 1988, 'Pediatric parenteral amino acid mixture in low birth weight infants', Pediatrics, vol. 81, no. 1, pp. 41-50.
Heird WC, Hay W, Helms R, Storm MC, Kashyap S, Dell RB. Pediatric parenteral amino acid mixture in low birth weight infants. Pediatrics. 1988;81(1):41-50.
Heird, W. C. ; Hay, W. ; Helms, Richard ; Storm, M. C. ; Kashyap, S. ; Dell, R. B. / Pediatric parenteral amino acid mixture in low birth weight infants. In: Pediatrics. 1988 ; Vol. 81, No. 1. pp. 41-50.
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