Penile fibrotic changes after radical retropubic prostatectomy

Sebastian J. Ciancio, Edward Kim

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective. To investigate the type of penile deformity, response to treatment of and predictive factors for the formation of penile fibrotic changes after radical retropubic prostatectomy (RRP). Patients and methods. Between July 1996 and September 1998, 110 men who had undergone RRP a mean (SD, range) of 35 (20, 5-145) months previously were evaluated by one physician for their erectile dysfunction. Those men affected by penile fibrotic changes were advised to initiate medical therapy for possible Peyronie's disease; their charts were reviewed and they were interviewed to determine the outcome. Results. Overall, 45 of 110 patients (41) with erectile dysfunction after RRP had penile fibrotic changes, representing 11 of all patients undergoing RRP in the specified period. The primary clinical presentation included penile curvature in 42 men (93) and 'waistband' deformity in 11 (24; some had both); palpable plaques were present in 31 (69). On assessing the outcome in 40 men, 16 (40) felt that their condition had improved, half were unchanged and 10 progressed, within a mean follow-up of 24 months after diagnosis. Of the 16 improved, 14 were regularly using a vacuum constriction device or injection therapy. No significant factors predictive of the fibrotic changes could be identified, including the use of intracavernosal injection therapy before onset, neurovascular bundle resection, operative duration, estimated blood loss and pathological tumour grade or stage. Conclusions. Penile fibrotic changes are a significant but previously undescribed problem in men after RRP. Although predisposing factors could not be identified, most men felt that their condition stabilized or improved during treatment. Corroborative confirmation of this association and its aetiology will require prospective studies.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalBJU International
Volume85
Issue number1
DOIs
StatePublished - Feb 10 2000
Externally publishedYes

Fingerprint

Prostatectomy
Erectile Dysfunction
Penile Induration
Therapeutics
Injections
Vacuum
Constriction
Causality
Prospective Studies
Physicians
Equipment and Supplies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Penile fibrotic changes after radical retropubic prostatectomy. / Ciancio, Sebastian J.; Kim, Edward.

In: BJU International, Vol. 85, No. 1, 10.02.2000, p. 101-106.

Research output: Contribution to journalArticle

Ciancio, Sebastian J. ; Kim, Edward. / Penile fibrotic changes after radical retropubic prostatectomy. In: BJU International. 2000 ; Vol. 85, No. 1. pp. 101-106.
@article{46d2a9decc47404f84a66fe71b90d221,
title = "Penile fibrotic changes after radical retropubic prostatectomy",
abstract = "Objective. To investigate the type of penile deformity, response to treatment of and predictive factors for the formation of penile fibrotic changes after radical retropubic prostatectomy (RRP). Patients and methods. Between July 1996 and September 1998, 110 men who had undergone RRP a mean (SD, range) of 35 (20, 5-145) months previously were evaluated by one physician for their erectile dysfunction. Those men affected by penile fibrotic changes were advised to initiate medical therapy for possible Peyronie's disease; their charts were reviewed and they were interviewed to determine the outcome. Results. Overall, 45 of 110 patients (41) with erectile dysfunction after RRP had penile fibrotic changes, representing 11 of all patients undergoing RRP in the specified period. The primary clinical presentation included penile curvature in 42 men (93) and 'waistband' deformity in 11 (24; some had both); palpable plaques were present in 31 (69). On assessing the outcome in 40 men, 16 (40) felt that their condition had improved, half were unchanged and 10 progressed, within a mean follow-up of 24 months after diagnosis. Of the 16 improved, 14 were regularly using a vacuum constriction device or injection therapy. No significant factors predictive of the fibrotic changes could be identified, including the use of intracavernosal injection therapy before onset, neurovascular bundle resection, operative duration, estimated blood loss and pathological tumour grade or stage. Conclusions. Penile fibrotic changes are a significant but previously undescribed problem in men after RRP. Although predisposing factors could not be identified, most men felt that their condition stabilized or improved during treatment. Corroborative confirmation of this association and its aetiology will require prospective studies.",
author = "Ciancio, {Sebastian J.} and Edward Kim",
year = "2000",
month = "2",
day = "10",
doi = "10.1046/j.1464-410X.2000.00364.x",
language = "English (US)",
volume = "85",
pages = "101--106",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Penile fibrotic changes after radical retropubic prostatectomy

AU - Ciancio, Sebastian J.

AU - Kim, Edward

PY - 2000/2/10

Y1 - 2000/2/10

N2 - Objective. To investigate the type of penile deformity, response to treatment of and predictive factors for the formation of penile fibrotic changes after radical retropubic prostatectomy (RRP). Patients and methods. Between July 1996 and September 1998, 110 men who had undergone RRP a mean (SD, range) of 35 (20, 5-145) months previously were evaluated by one physician for their erectile dysfunction. Those men affected by penile fibrotic changes were advised to initiate medical therapy for possible Peyronie's disease; their charts were reviewed and they were interviewed to determine the outcome. Results. Overall, 45 of 110 patients (41) with erectile dysfunction after RRP had penile fibrotic changes, representing 11 of all patients undergoing RRP in the specified period. The primary clinical presentation included penile curvature in 42 men (93) and 'waistband' deformity in 11 (24; some had both); palpable plaques were present in 31 (69). On assessing the outcome in 40 men, 16 (40) felt that their condition had improved, half were unchanged and 10 progressed, within a mean follow-up of 24 months after diagnosis. Of the 16 improved, 14 were regularly using a vacuum constriction device or injection therapy. No significant factors predictive of the fibrotic changes could be identified, including the use of intracavernosal injection therapy before onset, neurovascular bundle resection, operative duration, estimated blood loss and pathological tumour grade or stage. Conclusions. Penile fibrotic changes are a significant but previously undescribed problem in men after RRP. Although predisposing factors could not be identified, most men felt that their condition stabilized or improved during treatment. Corroborative confirmation of this association and its aetiology will require prospective studies.

AB - Objective. To investigate the type of penile deformity, response to treatment of and predictive factors for the formation of penile fibrotic changes after radical retropubic prostatectomy (RRP). Patients and methods. Between July 1996 and September 1998, 110 men who had undergone RRP a mean (SD, range) of 35 (20, 5-145) months previously were evaluated by one physician for their erectile dysfunction. Those men affected by penile fibrotic changes were advised to initiate medical therapy for possible Peyronie's disease; their charts were reviewed and they were interviewed to determine the outcome. Results. Overall, 45 of 110 patients (41) with erectile dysfunction after RRP had penile fibrotic changes, representing 11 of all patients undergoing RRP in the specified period. The primary clinical presentation included penile curvature in 42 men (93) and 'waistband' deformity in 11 (24; some had both); palpable plaques were present in 31 (69). On assessing the outcome in 40 men, 16 (40) felt that their condition had improved, half were unchanged and 10 progressed, within a mean follow-up of 24 months after diagnosis. Of the 16 improved, 14 were regularly using a vacuum constriction device or injection therapy. No significant factors predictive of the fibrotic changes could be identified, including the use of intracavernosal injection therapy before onset, neurovascular bundle resection, operative duration, estimated blood loss and pathological tumour grade or stage. Conclusions. Penile fibrotic changes are a significant but previously undescribed problem in men after RRP. Although predisposing factors could not be identified, most men felt that their condition stabilized or improved during treatment. Corroborative confirmation of this association and its aetiology will require prospective studies.

UR - http://www.scopus.com/inward/record.url?scp=0033969114&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033969114&partnerID=8YFLogxK

U2 - 10.1046/j.1464-410X.2000.00364.x

DO - 10.1046/j.1464-410X.2000.00364.x

M3 - Article

VL - 85

SP - 101

EP - 106

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 1

ER -