Pentamidine congeners 1

Synthesis of Cis- and Trans-butamidine analogues as anti-Pneumocystis carinii pneumonia agents.

Isaac Donkor, Susan K. Jones, Richard R. Tidwell

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pneumonia activity in a rat model of the disease.

Original languageEnglish (US)
Pages (from-to)1137-1140
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number6
DOIs
StatePublished - Jan 1 1993

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Pentamidine
Pneumocystis Pneumonia
Ether
Rats
butamidine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Pentamidine congeners 1 : Synthesis of Cis- and Trans-butamidine analogues as anti-Pneumocystis carinii pneumonia agents. / Donkor, Isaac; Jones, Susan K.; Tidwell, Richard R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 6, 01.01.1993, p. 1137-1140.

Research output: Contribution to journalArticle

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