Pentamidine congeners. 4. DNA binding affinity and anti-Pneumocystis carinii activity of butamidine analogues

Isaac Donkor, Sherry F. Queener, James T. Dalton

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A number of pentamidine-like compounds are known to bind to DNA. DNA could therefore be the molecular target for the anti-P. carinii activity of these compounds. We provide the first evidence demonstrating a correlation between in vitro anti-P. carinii activity and in vitro DNA binding affinity of pentamidine related aromatic dicationic compounds.

Original languageEnglish (US)
Pages (from-to)1967-1970
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number16
DOIs
StatePublished - Aug 20 1996

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Pentamidine
Pneumocystis carinii
DNA
Aromatic compounds
butamidine
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Pentamidine congeners. 4. DNA binding affinity and anti-Pneumocystis carinii activity of butamidine analogues. / Donkor, Isaac; Queener, Sherry F.; Dalton, James T.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 6, No. 16, 20.08.1996, p. 1967-1970.

Research output: Contribution to journalArticle

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