Perampanel Pharmacokinetics in Children

Correlation of Dose With Serum Concentrations

Elizabeth Gaudio, Andrew J. Gienapp, James Wheless

Research output: Contribution to journalArticle

Abstract

Enzyme-inducing antiseizure drugs taken concomitantly with perampanel are known to influence perampanel serum concentrations. In this study, we examined perampanel dosage, serum concentrations, and the effect of concomitant enzyme-inducing antiseizure drugs in children for a 3-year period. A retrospective chart review determined patient age, weight, perampanel serum concentration and prescribed dose, and concomitant drugs. Of 87 patients included in the study, 41 were prescribed an enzyme-inducing antiseizure drug. Although perampanel dosage did not differ between patients prescribed/not prescribed enzyme-inducing antiseizure drugs, serum concentrations were significantly lower in patients taking enzyme-inducing antiseizure drugs (average serum concentration for the enzyme-inducing antiseizure drug group was still above the previously reported efficacious serum concentration of 70 ng/mL). Although perampanel serum concentrations are negatively influenced by enzyme-inducing antiseizure drugs in children, it is likely that efficacy would be improved in patients not concomitantly prescribed enzyme-inducing antiseizure drugs because pediatric perampanel dosing is similar to that reported in prior adult efficacy trials.

Original languageEnglish (US)
Pages (from-to)427-431
Number of pages5
JournalJournal of child neurology
Volume34
Issue number8
DOIs
StatePublished - Jul 1 2019

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Pharmacokinetics
Serum
Pharmaceutical Preparations
Enzymes
perampanel
Pediatrics
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Perampanel Pharmacokinetics in Children : Correlation of Dose With Serum Concentrations. / Gaudio, Elizabeth; Gienapp, Andrew J.; Wheless, James.

In: Journal of child neurology, Vol. 34, No. 8, 01.07.2019, p. 427-431.

Research output: Contribution to journalArticle

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