Perceptions of risk of infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Jordan Gilleland Marchak, Kristy D. Seidel, Ann C. Mertens, Chad W.M. Ritenour, Karen Wasilewski-Masker, Wendy M. Leisenring, Charles A. Sklar, Jennifer S. Ford, Kevin R. Krull, Marilyn Stovall, Leslie L. Robison, Gregory Armstrong, Lillian R. Meacham

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: The objective of the current study was to characterize and identify factors associated with perceptions of risk of infertility among adult male survivors of childhood cancer. METHODS: A total of 1233 adult male survivors from the Childhood Cancer Survivor Study who were without a history of disease recurrence or subsequent malignancy reported their perceptions of their risk of infertility compared with men never diagnosed with cancer. Survivors were a median age of 37.8 years (range, 22.0-58.7 years) and were 28.4 years from their diagnosis (range, 21.4-39.2 years). Multivariable logistic regression evaluated factors associated with perceptions of risk. RESULTS: Overall, 35.9% of the survivors (443 of 1233 survivors) reported perceptions of their risk of infertility that were discordant with their actual risk based on previous cancer treatment exposures. Discordant perceptions were equally common among men exposed to gonadotoxic therapies (36.3%; 311 of 857 men) and those with no history of gonadotoxic exposure (35.1%; 132 of 376 men). Survivors who fathered children (odds ratio [OR], 4.14; 95% confidence interval [95% CI], 2.74-6.24), had no survivor-focused health care (OR, 3.07; 95% CI, 1.57-5.99), were nonwhite (OR, 2.28; 95% CI, 1.10-4.75), and were of lower income were more likely to report no increased risk of infertility after gonadotoxic treatment. Perceptions of increased risk of infertility among men with no history of gonadotoxic treatment were predicted by never having fathered a child (OR, 1.88; 95% CI, 1.17-3.03), recent participation in survivor-focused health care (OR, 2.11; 95% CI, 1.01-4.42), and higher educational achievement. CONCLUSIONS: Many male survivors of childhood cancer are unaware of how their cancer treatments could impact their reproductive health, underscoring the need for all patients to receive education regarding their risk of infertility throughout the continuum of cancer care. Cancer 2018;124:2447-55.

Original languageEnglish (US)
Pages (from-to)2447-2455
Number of pages9
JournalCancer
Volume124
Issue number11
DOIs
StatePublished - Jun 1 2018

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Male Infertility
Survivors
Infertility
Neoplasms
Odds Ratio
Confidence Intervals
Delivery of Health Care
Therapeutics
Educational Status
Continuity of Patient Care
Reproductive Health
Logistic Models
Education
Recurrence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Gilleland Marchak, J., Seidel, K. D., Mertens, A. C., Ritenour, C. W. M., Wasilewski-Masker, K., Leisenring, W. M., ... Meacham, L. R. (2018). Perceptions of risk of infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer, 124(11), 2447-2455. https://doi.org/10.1002/cncr.31343

Perceptions of risk of infertility among male survivors of childhood cancer : A report from the Childhood Cancer Survivor Study. / Gilleland Marchak, Jordan; Seidel, Kristy D.; Mertens, Ann C.; Ritenour, Chad W.M.; Wasilewski-Masker, Karen; Leisenring, Wendy M.; Sklar, Charles A.; Ford, Jennifer S.; Krull, Kevin R.; Stovall, Marilyn; Robison, Leslie L.; Armstrong, Gregory; Meacham, Lillian R.

In: Cancer, Vol. 124, No. 11, 01.06.2018, p. 2447-2455.

Research output: Contribution to journalArticle

Gilleland Marchak, J, Seidel, KD, Mertens, AC, Ritenour, CWM, Wasilewski-Masker, K, Leisenring, WM, Sklar, CA, Ford, JS, Krull, KR, Stovall, M, Robison, LL, Armstrong, G & Meacham, LR 2018, 'Perceptions of risk of infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study', Cancer, vol. 124, no. 11, pp. 2447-2455. https://doi.org/10.1002/cncr.31343
Gilleland Marchak J, Seidel KD, Mertens AC, Ritenour CWM, Wasilewski-Masker K, Leisenring WM et al. Perceptions of risk of infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer. 2018 Jun 1;124(11):2447-2455. https://doi.org/10.1002/cncr.31343
Gilleland Marchak, Jordan ; Seidel, Kristy D. ; Mertens, Ann C. ; Ritenour, Chad W.M. ; Wasilewski-Masker, Karen ; Leisenring, Wendy M. ; Sklar, Charles A. ; Ford, Jennifer S. ; Krull, Kevin R. ; Stovall, Marilyn ; Robison, Leslie L. ; Armstrong, Gregory ; Meacham, Lillian R. / Perceptions of risk of infertility among male survivors of childhood cancer : A report from the Childhood Cancer Survivor Study. In: Cancer. 2018 ; Vol. 124, No. 11. pp. 2447-2455.
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abstract = "BACKGROUND: The objective of the current study was to characterize and identify factors associated with perceptions of risk of infertility among adult male survivors of childhood cancer. METHODS: A total of 1233 adult male survivors from the Childhood Cancer Survivor Study who were without a history of disease recurrence or subsequent malignancy reported their perceptions of their risk of infertility compared with men never diagnosed with cancer. Survivors were a median age of 37.8 years (range, 22.0-58.7 years) and were 28.4 years from their diagnosis (range, 21.4-39.2 years). Multivariable logistic regression evaluated factors associated with perceptions of risk. RESULTS: Overall, 35.9{\%} of the survivors (443 of 1233 survivors) reported perceptions of their risk of infertility that were discordant with their actual risk based on previous cancer treatment exposures. Discordant perceptions were equally common among men exposed to gonadotoxic therapies (36.3{\%}; 311 of 857 men) and those with no history of gonadotoxic exposure (35.1{\%}; 132 of 376 men). Survivors who fathered children (odds ratio [OR], 4.14; 95{\%} confidence interval [95{\%} CI], 2.74-6.24), had no survivor-focused health care (OR, 3.07; 95{\%} CI, 1.57-5.99), were nonwhite (OR, 2.28; 95{\%} CI, 1.10-4.75), and were of lower income were more likely to report no increased risk of infertility after gonadotoxic treatment. Perceptions of increased risk of infertility among men with no history of gonadotoxic treatment were predicted by never having fathered a child (OR, 1.88; 95{\%} CI, 1.17-3.03), recent participation in survivor-focused health care (OR, 2.11; 95{\%} CI, 1.01-4.42), and higher educational achievement. CONCLUSIONS: Many male survivors of childhood cancer are unaware of how their cancer treatments could impact their reproductive health, underscoring the need for all patients to receive education regarding their risk of infertility throughout the continuum of cancer care. Cancer 2018;124:2447-55.",
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T1 - Perceptions of risk of infertility among male survivors of childhood cancer

T2 - A report from the Childhood Cancer Survivor Study

AU - Gilleland Marchak, Jordan

AU - Seidel, Kristy D.

AU - Mertens, Ann C.

AU - Ritenour, Chad W.M.

AU - Wasilewski-Masker, Karen

AU - Leisenring, Wendy M.

AU - Sklar, Charles A.

AU - Ford, Jennifer S.

AU - Krull, Kevin R.

AU - Stovall, Marilyn

AU - Robison, Leslie L.

AU - Armstrong, Gregory

AU - Meacham, Lillian R.

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N2 - BACKGROUND: The objective of the current study was to characterize and identify factors associated with perceptions of risk of infertility among adult male survivors of childhood cancer. METHODS: A total of 1233 adult male survivors from the Childhood Cancer Survivor Study who were without a history of disease recurrence or subsequent malignancy reported their perceptions of their risk of infertility compared with men never diagnosed with cancer. Survivors were a median age of 37.8 years (range, 22.0-58.7 years) and were 28.4 years from their diagnosis (range, 21.4-39.2 years). Multivariable logistic regression evaluated factors associated with perceptions of risk. RESULTS: Overall, 35.9% of the survivors (443 of 1233 survivors) reported perceptions of their risk of infertility that were discordant with their actual risk based on previous cancer treatment exposures. Discordant perceptions were equally common among men exposed to gonadotoxic therapies (36.3%; 311 of 857 men) and those with no history of gonadotoxic exposure (35.1%; 132 of 376 men). Survivors who fathered children (odds ratio [OR], 4.14; 95% confidence interval [95% CI], 2.74-6.24), had no survivor-focused health care (OR, 3.07; 95% CI, 1.57-5.99), were nonwhite (OR, 2.28; 95% CI, 1.10-4.75), and were of lower income were more likely to report no increased risk of infertility after gonadotoxic treatment. Perceptions of increased risk of infertility among men with no history of gonadotoxic treatment were predicted by never having fathered a child (OR, 1.88; 95% CI, 1.17-3.03), recent participation in survivor-focused health care (OR, 2.11; 95% CI, 1.01-4.42), and higher educational achievement. CONCLUSIONS: Many male survivors of childhood cancer are unaware of how their cancer treatments could impact their reproductive health, underscoring the need for all patients to receive education regarding their risk of infertility throughout the continuum of cancer care. Cancer 2018;124:2447-55.

AB - BACKGROUND: The objective of the current study was to characterize and identify factors associated with perceptions of risk of infertility among adult male survivors of childhood cancer. METHODS: A total of 1233 adult male survivors from the Childhood Cancer Survivor Study who were without a history of disease recurrence or subsequent malignancy reported their perceptions of their risk of infertility compared with men never diagnosed with cancer. Survivors were a median age of 37.8 years (range, 22.0-58.7 years) and were 28.4 years from their diagnosis (range, 21.4-39.2 years). Multivariable logistic regression evaluated factors associated with perceptions of risk. RESULTS: Overall, 35.9% of the survivors (443 of 1233 survivors) reported perceptions of their risk of infertility that were discordant with their actual risk based on previous cancer treatment exposures. Discordant perceptions were equally common among men exposed to gonadotoxic therapies (36.3%; 311 of 857 men) and those with no history of gonadotoxic exposure (35.1%; 132 of 376 men). Survivors who fathered children (odds ratio [OR], 4.14; 95% confidence interval [95% CI], 2.74-6.24), had no survivor-focused health care (OR, 3.07; 95% CI, 1.57-5.99), were nonwhite (OR, 2.28; 95% CI, 1.10-4.75), and were of lower income were more likely to report no increased risk of infertility after gonadotoxic treatment. Perceptions of increased risk of infertility among men with no history of gonadotoxic treatment were predicted by never having fathered a child (OR, 1.88; 95% CI, 1.17-3.03), recent participation in survivor-focused health care (OR, 2.11; 95% CI, 1.01-4.42), and higher educational achievement. CONCLUSIONS: Many male survivors of childhood cancer are unaware of how their cancer treatments could impact their reproductive health, underscoring the need for all patients to receive education regarding their risk of infertility throughout the continuum of cancer care. Cancer 2018;124:2447-55.

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