Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/ calcification syndrome in end-stage renal disease patients

K. Turkmen, H. Z. Tonbul, F. M. Erdur, I. Guney, H. Kayikcioglu, L. Altintepe, O. Ozbek, M. I. Yilmaz, Abduzhappar Gaipov, S. Turk, A. Covic, M. Kanbay

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Abstract

Purpose: Thoracic peri-aortic fat tissue (PFT) is considered as a metabolically active organ in atherosclerosis. Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients. Methods: Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin <3.5 g/dL were defined as patients with malnutrition; those with serum C-reactive protein level >10 mg/L had inflammation, and those with coronary artery calcification score (CACS) >10 had atherosclerosis/calcification. Results: TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p < 0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm 3 ) and lowest among those who do not have the MIAC syndrome (8.54 cm 3 ). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU). Conclusions: We found a relationship between PFT and MIAC syndrome in ESRD patients.

Original languageEnglish (US)
Pages (from-to)857-867
Number of pages11
JournalInternational Urology and Nephrology
Volume45
Issue number3
DOIs
StatePublished - Jun 1 2013

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Malnutrition
Chronic Kidney Failure
Atherosclerosis
Fats
Inflammation
Thorax
Uric Acid
Peritoneal Dialysis
Serum Albumin
Renal Dialysis
Aorta
Coronary Vessels
Hemoglobins
Cardiovascular Diseases
Multivariate Analysis
Cross-Sectional Studies
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

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Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/ calcification syndrome in end-stage renal disease patients. / Turkmen, K.; Tonbul, H. Z.; Erdur, F. M.; Guney, I.; Kayikcioglu, H.; Altintepe, L.; Ozbek, O.; Yilmaz, M. I.; Gaipov, Abduzhappar; Turk, S.; Covic, A.; Kanbay, M.

In: International Urology and Nephrology, Vol. 45, No. 3, 01.06.2013, p. 857-867.

Research output: Contribution to journalArticle

Turkmen, K, Tonbul, HZ, Erdur, FM, Guney, I, Kayikcioglu, H, Altintepe, L, Ozbek, O, Yilmaz, MI, Gaipov, A, Turk, S, Covic, A & Kanbay, M 2013, 'Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/ calcification syndrome in end-stage renal disease patients', International Urology and Nephrology, vol. 45, no. 3, pp. 857-867. https://doi.org/10.1007/s11255-012-0286-x
Turkmen, K. ; Tonbul, H. Z. ; Erdur, F. M. ; Guney, I. ; Kayikcioglu, H. ; Altintepe, L. ; Ozbek, O. ; Yilmaz, M. I. ; Gaipov, Abduzhappar ; Turk, S. ; Covic, A. ; Kanbay, M. / Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/ calcification syndrome in end-stage renal disease patients. In: International Urology and Nephrology. 2013 ; Vol. 45, No. 3. pp. 857-867.
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T1 - Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/ calcification syndrome in end-stage renal disease patients

AU - Turkmen, K.

AU - Tonbul, H. Z.

AU - Erdur, F. M.

AU - Guney, I.

AU - Kayikcioglu, H.

AU - Altintepe, L.

AU - Ozbek, O.

AU - Yilmaz, M. I.

AU - Gaipov, Abduzhappar

AU - Turk, S.

AU - Covic, A.

AU - Kanbay, M.

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Purpose: Thoracic peri-aortic fat tissue (PFT) is considered as a metabolically active organ in atherosclerosis. Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients. Methods: Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin <3.5 g/dL were defined as patients with malnutrition; those with serum C-reactive protein level >10 mg/L had inflammation, and those with coronary artery calcification score (CACS) >10 had atherosclerosis/calcification. Results: TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p < 0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm 3 ) and lowest among those who do not have the MIAC syndrome (8.54 cm 3 ). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU). Conclusions: We found a relationship between PFT and MIAC syndrome in ESRD patients.

AB - Purpose: Thoracic peri-aortic fat tissue (PFT) is considered as a metabolically active organ in atherosclerosis. Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients. Methods: Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin <3.5 g/dL were defined as patients with malnutrition; those with serum C-reactive protein level >10 mg/L had inflammation, and those with coronary artery calcification score (CACS) >10 had atherosclerosis/calcification. Results: TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p < 0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm 3 ) and lowest among those who do not have the MIAC syndrome (8.54 cm 3 ). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU). Conclusions: We found a relationship between PFT and MIAC syndrome in ESRD patients.

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