Peripherally administered β-Endorphin increases cerebrospinal fluid endorphin immunoreactivity

Robert H. Gerner, Burt Sharp, Don H. Catlin

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

There is a discrepancy between the reported effect of iv β-endorphin on behavioral and pain syndromes and previously reported minimal penetrance of β-endorphin into rat and human brains. We examined the cerebrospinal fluid of three depressed subjects before and after iv infusion of β-endorphin and found markedly increased β-endorphin immunoreactivity, ranging from 223-552% of baseline. This elevation was evident up to 17 h after the infusion.

Original languageEnglish (US)
Pages (from-to)358-360
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number2
DOIs
StatePublished - Jan 1 1982

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Endorphins
Cerebrospinal fluid
Cerebrospinal Fluid
Penetrance
Rats
Brain
Pain

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Peripherally administered β-Endorphin increases cerebrospinal fluid endorphin immunoreactivity. / Gerner, Robert H.; Sharp, Burt; Catlin, Don H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 2, 01.01.1982, p. 358-360.

Research output: Contribution to journalArticle

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