Peritoneal dialysis does not adversely affect kidney function recovery after congenital heart surgery

Alyssa A. Riley, John Jefferies, David P. Nelson, Michael R. Bennett, Joshua J. Blinder, Qing Ma, Prasad Devarajan, Stuart L. Goldstein

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: Acute kidney injury (AKI) after cardiopulmonary bypass surgery to correct congenital heart disease is common. We prevent fluid overload and further cardiac compromise in oliguric infants with continuous peritoneal dialysis (CPD). The effect of CPD on kidney recovery is unknown, thus indications to discontinue CPD are unclear. We aimed to determine if CPD affects kidney recovery, measured by urine output and novel urinary AKI biomarker concentrations. Methods: Twenty infants <90 days old with congenital heart disease who underwent bypass surgery and were post-operatively treated with CPD were randomized at the time of clinical readiness for CPD discontinuation to 1) discontinue CPD (control) or 2) continue 24 h more CPD (experimental). Urine output (ml/kg per h), total output (ml/kg per h) and urinary neutrophil gelatinase-associated lipocalin, interleukin-18, liver-type fatty acid binding protein, and kidney injury molecule-1 were assessed postsurgery until CPD catheter removal. Results: 24 hours preceding randomization, there were no differences in mean urine output or total output; 24 hours post-randomization, the control group had higher mean urine output (4.2 ± 2.6 ml/kg per h vs. 2.8 ± 2.0 ml/kg per h, p = 0.02) but lower total output (6.3 ± 2.1 ml/kg per h vs. 4.7 ± 2.7 ml/kg per h, p = 0.01). Median biomarker concentrations did not differ significantly between groups at any time point. Conclusions: Our results suggest renal replacement therapy does not change the time course of kidney function recovery.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalInternational Journal of Artificial Organs
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Dialysis
Recovery of Function
Peritoneal Dialysis
Surgery
Thoracic Surgery
Kidney
Recovery
Urine
Biomarkers
Random Allocation
Acute Kidney Injury
Heart Diseases
Lipocalins
Fatty Acid-Binding Proteins
Gelatinases
Interleukin-18
Renal Replacement Therapy
Catheters
Cardiopulmonary Bypass
Fatty acids

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

Cite this

Peritoneal dialysis does not adversely affect kidney function recovery after congenital heart surgery. / Riley, Alyssa A.; Jefferies, John; Nelson, David P.; Bennett, Michael R.; Blinder, Joshua J.; Ma, Qing; Devarajan, Prasad; Goldstein, Stuart L.

In: International Journal of Artificial Organs, Vol. 37, No. 1, 01.01.2014, p. 39-47.

Research output: Contribution to journalArticle

Riley, Alyssa A. ; Jefferies, John ; Nelson, David P. ; Bennett, Michael R. ; Blinder, Joshua J. ; Ma, Qing ; Devarajan, Prasad ; Goldstein, Stuart L. / Peritoneal dialysis does not adversely affect kidney function recovery after congenital heart surgery. In: International Journal of Artificial Organs. 2014 ; Vol. 37, No. 1. pp. 39-47.
@article{93f96eb6f25f4e2d9ddb3639305d531e,
title = "Peritoneal dialysis does not adversely affect kidney function recovery after congenital heart surgery",
abstract = "Purpose: Acute kidney injury (AKI) after cardiopulmonary bypass surgery to correct congenital heart disease is common. We prevent fluid overload and further cardiac compromise in oliguric infants with continuous peritoneal dialysis (CPD). The effect of CPD on kidney recovery is unknown, thus indications to discontinue CPD are unclear. We aimed to determine if CPD affects kidney recovery, measured by urine output and novel urinary AKI biomarker concentrations. Methods: Twenty infants <90 days old with congenital heart disease who underwent bypass surgery and were post-operatively treated with CPD were randomized at the time of clinical readiness for CPD discontinuation to 1) discontinue CPD (control) or 2) continue 24 h more CPD (experimental). Urine output (ml/kg per h), total output (ml/kg per h) and urinary neutrophil gelatinase-associated lipocalin, interleukin-18, liver-type fatty acid binding protein, and kidney injury molecule-1 were assessed postsurgery until CPD catheter removal. Results: 24 hours preceding randomization, there were no differences in mean urine output or total output; 24 hours post-randomization, the control group had higher mean urine output (4.2 ± 2.6 ml/kg per h vs. 2.8 ± 2.0 ml/kg per h, p = 0.02) but lower total output (6.3 ± 2.1 ml/kg per h vs. 4.7 ± 2.7 ml/kg per h, p = 0.01). Median biomarker concentrations did not differ significantly between groups at any time point. Conclusions: Our results suggest renal replacement therapy does not change the time course of kidney function recovery.",
author = "Riley, {Alyssa A.} and John Jefferies and Nelson, {David P.} and Bennett, {Michael R.} and Blinder, {Joshua J.} and Qing Ma and Prasad Devarajan and Goldstein, {Stuart L.}",
year = "2014",
month = "1",
day = "1",
doi = "10.5301/ijao.5000294",
language = "English (US)",
volume = "37",
pages = "39--47",
journal = "International Journal of Artificial Organs",
issn = "0391-3988",
publisher = "Wichtig Publishing",
number = "1",

}

TY - JOUR

T1 - Peritoneal dialysis does not adversely affect kidney function recovery after congenital heart surgery

AU - Riley, Alyssa A.

AU - Jefferies, John

AU - Nelson, David P.

AU - Bennett, Michael R.

AU - Blinder, Joshua J.

AU - Ma, Qing

AU - Devarajan, Prasad

AU - Goldstein, Stuart L.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: Acute kidney injury (AKI) after cardiopulmonary bypass surgery to correct congenital heart disease is common. We prevent fluid overload and further cardiac compromise in oliguric infants with continuous peritoneal dialysis (CPD). The effect of CPD on kidney recovery is unknown, thus indications to discontinue CPD are unclear. We aimed to determine if CPD affects kidney recovery, measured by urine output and novel urinary AKI biomarker concentrations. Methods: Twenty infants <90 days old with congenital heart disease who underwent bypass surgery and were post-operatively treated with CPD were randomized at the time of clinical readiness for CPD discontinuation to 1) discontinue CPD (control) or 2) continue 24 h more CPD (experimental). Urine output (ml/kg per h), total output (ml/kg per h) and urinary neutrophil gelatinase-associated lipocalin, interleukin-18, liver-type fatty acid binding protein, and kidney injury molecule-1 were assessed postsurgery until CPD catheter removal. Results: 24 hours preceding randomization, there were no differences in mean urine output or total output; 24 hours post-randomization, the control group had higher mean urine output (4.2 ± 2.6 ml/kg per h vs. 2.8 ± 2.0 ml/kg per h, p = 0.02) but lower total output (6.3 ± 2.1 ml/kg per h vs. 4.7 ± 2.7 ml/kg per h, p = 0.01). Median biomarker concentrations did not differ significantly between groups at any time point. Conclusions: Our results suggest renal replacement therapy does not change the time course of kidney function recovery.

AB - Purpose: Acute kidney injury (AKI) after cardiopulmonary bypass surgery to correct congenital heart disease is common. We prevent fluid overload and further cardiac compromise in oliguric infants with continuous peritoneal dialysis (CPD). The effect of CPD on kidney recovery is unknown, thus indications to discontinue CPD are unclear. We aimed to determine if CPD affects kidney recovery, measured by urine output and novel urinary AKI biomarker concentrations. Methods: Twenty infants <90 days old with congenital heart disease who underwent bypass surgery and were post-operatively treated with CPD were randomized at the time of clinical readiness for CPD discontinuation to 1) discontinue CPD (control) or 2) continue 24 h more CPD (experimental). Urine output (ml/kg per h), total output (ml/kg per h) and urinary neutrophil gelatinase-associated lipocalin, interleukin-18, liver-type fatty acid binding protein, and kidney injury molecule-1 were assessed postsurgery until CPD catheter removal. Results: 24 hours preceding randomization, there were no differences in mean urine output or total output; 24 hours post-randomization, the control group had higher mean urine output (4.2 ± 2.6 ml/kg per h vs. 2.8 ± 2.0 ml/kg per h, p = 0.02) but lower total output (6.3 ± 2.1 ml/kg per h vs. 4.7 ± 2.7 ml/kg per h, p = 0.01). Median biomarker concentrations did not differ significantly between groups at any time point. Conclusions: Our results suggest renal replacement therapy does not change the time course of kidney function recovery.

UR - http://www.scopus.com/inward/record.url?scp=84896714430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896714430&partnerID=8YFLogxK

U2 - 10.5301/ijao.5000294

DO - 10.5301/ijao.5000294

M3 - Article

VL - 37

SP - 39

EP - 47

JO - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

SN - 0391-3988

IS - 1

ER -