Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles

Hae Woong Choi, Jutamas Suwanpradid, Il Hwan Kim, Herman F. Staats, Muzlifah Haniffa, Amanda S. MacLeod, Soman N. Abraham

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b+ perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.

Original languageEnglish (US)
JournalScience (New York, N.Y.)
Volume362
Issue number6415
DOIs
StatePublished - Nov 9 2018

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Anaphylaxis
Mast Cells
Allergens
Dendritic Cells
Antigens
Blood Circulation
Protein Transport
Surface Antigens
Immunoglobulin E

All Science Journal Classification (ASJC) codes

  • General

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Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. / Choi, Hae Woong; Suwanpradid, Jutamas; Kim, Il Hwan; Staats, Herman F.; Haniffa, Muzlifah; MacLeod, Amanda S.; Abraham, Soman N.

In: Science (New York, N.Y.), Vol. 362, No. 6415, 09.11.2018.

Research output: Contribution to journalArticle

Choi, Hae Woong ; Suwanpradid, Jutamas ; Kim, Il Hwan ; Staats, Herman F. ; Haniffa, Muzlifah ; MacLeod, Amanda S. ; Abraham, Soman N. / Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. In: Science (New York, N.Y.). 2018 ; Vol. 362, No. 6415.
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abstract = "Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b+ perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.",
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AU - Staats, Herman F.

AU - Haniffa, Muzlifah

AU - MacLeod, Amanda S.

AU - Abraham, Soman N.

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