Persistent pulmonary hypertension after maternal naproxen ingestion in a term newborn

A case report

Ajay Talati, M. A. Salim, S. B. Korones

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Constricting effect of indomethacin on the ductus arteriosus of the fetus is well known. The fetal effects of other nonsteroid anti-inflammatory drugs (NSAIDs) like naproxen are not well reported. We report here a case of a 3790-g term neonate who developed persistent pulmonary hypertension after birth with a closed ductus arteriosus. The mother admitted to taking naproxen sodium immediately prior to the birth of the infant. The course of illness was progressively better on conservative management. Like indomethacin, other NSAIDs can also cause premature closure of fetal ductus arteriosus, pulmonary hypertension, and life-threatening problems to the neonate. Patient education regarding over-the-counter pain medication during pregnancy should be emphasized.

Original languageEnglish (US)
Pages (from-to)69-71
Number of pages3
JournalAmerican Journal of Perinatology
Volume17
Issue number2
StatePublished - Jan 1 2000

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Ductus Arteriosus
Naproxen
Pulmonary Hypertension
Eating
Mothers
Newborn Infant
Indomethacin
Anti-Inflammatory Agents
Parturition
Patient Education
Pharmaceutical Preparations
Fetus
Pain
Pregnancy

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Persistent pulmonary hypertension after maternal naproxen ingestion in a term newborn : A case report. / Talati, Ajay; Salim, M. A.; Korones, S. B.

In: American Journal of Perinatology, Vol. 17, No. 2, 01.01.2000, p. 69-71.

Research output: Contribution to journalArticle

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