PET/CT characterization of fibroosseous defects in children

18F-FDG uptake can mimic metastatic disease

Geoffrey Goodin, Barry L. Shulkin, Robert A. Kaufman, M. Beth McCarville

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of this study was to characterize the anatomic appearance and metabolic activity of nonossifying fibromas, fibrous cortical defects, and cortical desmoids on PET/CT images. CONCLUSION. Over a 14-month period, we identified eight nonossifying fibromas, four fibrous cortical defects, and two cortical desmoids in 330 children who underwent PET/CT for the evaluation of a known or suspected malignancy. CT, conventional radiography, MRI, or clinical follow-up was used to confirm the diagnoses of these fibroosseous lesions. Eleven of the 14 children underwent multiple PET/CT examinations; thus, 34 studies were included. The lesions showed variable metabolic activity as indicated by 18F-FDG uptake: 19 PET/CT examinations showed lesions with mild 18F-FDG uptake, eight showed moderate 18F-FDG uptake, and seven showed intense uptake. When PET reveals metabolically active osseous abnormalities in children who are at risk for bone metastases, benign fibroosseous lesions should be considered in the differential diagnosis before additional diagnostic procedures are undertaken. Benign fibroosseous lesions may be metabolically active and thus mimic metastatic osseous disease in children with underlying malignancies. Correlative CT or other anatomic imaging can confirm the benign nature of these lesions.

Original languageEnglish (US)
Pages (from-to)1124-1128
Number of pages5
JournalAmerican Journal of Roentgenology
Volume187
Issue number4
DOIs
StatePublished - Oct 2006

Fingerprint

Fluorodeoxyglucose F18
Aggressive Fibromatosis
Fibroma
Radiography
Neoplasms
Differential Diagnosis
Neoplasm Metastasis
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

PET/CT characterization of fibroosseous defects in children : 18F-FDG uptake can mimic metastatic disease. / Goodin, Geoffrey; Shulkin, Barry L.; Kaufman, Robert A.; McCarville, M. Beth.

In: American Journal of Roentgenology, Vol. 187, No. 4, 10.2006, p. 1124-1128.

Research output: Contribution to journalArticle

Goodin, Geoffrey ; Shulkin, Barry L. ; Kaufman, Robert A. ; McCarville, M. Beth. / PET/CT characterization of fibroosseous defects in children : 18F-FDG uptake can mimic metastatic disease. In: American Journal of Roentgenology. 2006 ; Vol. 187, No. 4. pp. 1124-1128.
@article{7e1b176009124f9c919baf1302fdb3f2,
title = "PET/CT characterization of fibroosseous defects in children: 18F-FDG uptake can mimic metastatic disease",
abstract = "OBJECTIVE. The purpose of this study was to characterize the anatomic appearance and metabolic activity of nonossifying fibromas, fibrous cortical defects, and cortical desmoids on PET/CT images. CONCLUSION. Over a 14-month period, we identified eight nonossifying fibromas, four fibrous cortical defects, and two cortical desmoids in 330 children who underwent PET/CT for the evaluation of a known or suspected malignancy. CT, conventional radiography, MRI, or clinical follow-up was used to confirm the diagnoses of these fibroosseous lesions. Eleven of the 14 children underwent multiple PET/CT examinations; thus, 34 studies were included. The lesions showed variable metabolic activity as indicated by 18F-FDG uptake: 19 PET/CT examinations showed lesions with mild 18F-FDG uptake, eight showed moderate 18F-FDG uptake, and seven showed intense uptake. When PET reveals metabolically active osseous abnormalities in children who are at risk for bone metastases, benign fibroosseous lesions should be considered in the differential diagnosis before additional diagnostic procedures are undertaken. Benign fibroosseous lesions may be metabolically active and thus mimic metastatic osseous disease in children with underlying malignancies. Correlative CT or other anatomic imaging can confirm the benign nature of these lesions.",
author = "Geoffrey Goodin and Shulkin, {Barry L.} and Kaufman, {Robert A.} and McCarville, {M. Beth}",
year = "2006",
month = "10",
doi = "10.2214/AJR.06.0171",
language = "English (US)",
volume = "187",
pages = "1124--1128",
journal = "American Journal of Roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "4",

}

TY - JOUR

T1 - PET/CT characterization of fibroosseous defects in children

T2 - 18F-FDG uptake can mimic metastatic disease

AU - Goodin, Geoffrey

AU - Shulkin, Barry L.

AU - Kaufman, Robert A.

AU - McCarville, M. Beth

PY - 2006/10

Y1 - 2006/10

N2 - OBJECTIVE. The purpose of this study was to characterize the anatomic appearance and metabolic activity of nonossifying fibromas, fibrous cortical defects, and cortical desmoids on PET/CT images. CONCLUSION. Over a 14-month period, we identified eight nonossifying fibromas, four fibrous cortical defects, and two cortical desmoids in 330 children who underwent PET/CT for the evaluation of a known or suspected malignancy. CT, conventional radiography, MRI, or clinical follow-up was used to confirm the diagnoses of these fibroosseous lesions. Eleven of the 14 children underwent multiple PET/CT examinations; thus, 34 studies were included. The lesions showed variable metabolic activity as indicated by 18F-FDG uptake: 19 PET/CT examinations showed lesions with mild 18F-FDG uptake, eight showed moderate 18F-FDG uptake, and seven showed intense uptake. When PET reveals metabolically active osseous abnormalities in children who are at risk for bone metastases, benign fibroosseous lesions should be considered in the differential diagnosis before additional diagnostic procedures are undertaken. Benign fibroosseous lesions may be metabolically active and thus mimic metastatic osseous disease in children with underlying malignancies. Correlative CT or other anatomic imaging can confirm the benign nature of these lesions.

AB - OBJECTIVE. The purpose of this study was to characterize the anatomic appearance and metabolic activity of nonossifying fibromas, fibrous cortical defects, and cortical desmoids on PET/CT images. CONCLUSION. Over a 14-month period, we identified eight nonossifying fibromas, four fibrous cortical defects, and two cortical desmoids in 330 children who underwent PET/CT for the evaluation of a known or suspected malignancy. CT, conventional radiography, MRI, or clinical follow-up was used to confirm the diagnoses of these fibroosseous lesions. Eleven of the 14 children underwent multiple PET/CT examinations; thus, 34 studies were included. The lesions showed variable metabolic activity as indicated by 18F-FDG uptake: 19 PET/CT examinations showed lesions with mild 18F-FDG uptake, eight showed moderate 18F-FDG uptake, and seven showed intense uptake. When PET reveals metabolically active osseous abnormalities in children who are at risk for bone metastases, benign fibroosseous lesions should be considered in the differential diagnosis before additional diagnostic procedures are undertaken. Benign fibroosseous lesions may be metabolically active and thus mimic metastatic osseous disease in children with underlying malignancies. Correlative CT or other anatomic imaging can confirm the benign nature of these lesions.

UR - http://www.scopus.com/inward/record.url?scp=33748991994&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748991994&partnerID=8YFLogxK

U2 - 10.2214/AJR.06.0171

DO - 10.2214/AJR.06.0171

M3 - Article

VL - 187

SP - 1124

EP - 1128

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

SN - 0361-803X

IS - 4

ER -