Pharmacist interventions improve fluid balance in fluid-restricted patients requiring parenteral nutrition

Joyce Broyles, Rex Brown, Kathryn L. Vehe, Robert J. Nolly, R. Wayne Luther

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Many intensive care unit (ICU) patients require parenteral nutrition (PN) and fluid restriction, making delivery of adequate nutrition difficult. We studied the effects of pharmacist interventions on fluid balance in fluid-restricted ICU patients requiring PN. Twenty patients were randomized to the treatment group (dextrose 70% injection [D70W] plus 15% amino acids for PN, 25-mL piggybacks, selected drugs added to the PN solution) or the control group (D70W plus 10% amino acids, 50- or 100-mL piggybacks). Each group contained 10 patients and they were not significantly different for age, gender, weight, hospital days, and serum albumin concentration. The duration (9.3 ± 1.2 vs. 9.7 ± 2.4 d) and doses of PN (29 ± 6.8 vs. 28.7 ± 6.9 kcal/kg/d; 1.1 ± 0.3 vs. 1.1 ± 0.4 g/kg/d protein) were similar between treatment and control groups. Mean fluid intake (3112 ± 1146 vs. 3498 ± 1111 mL/d), fluid balance (146 ± 1581 vs. 708 ± 1402 mL/d), and cumulative fluid balance (1358 vs. 6867 mL) were all significantly lower in the treatment group. Mean fluid output was similar between the two groups. Pharmacist interventions can significantly decrease intake and result in a better fluid balance in fluid-restricted ICU patients who require PN.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalAnnals of Pharmacotherapy
Volume25
Issue number2
DOIs
StatePublished - Jan 1 1991

Fingerprint

Water-Electrolyte Balance
Parenteral Nutrition
Pharmacists
Intensive Care Units
Parenteral Nutrition Solutions
Amino Acids
Control Groups
Serum Albumin
Therapeutics
Weights and Measures
Glucose
Injections
Pharmaceutical Preparations
Proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pharmacist interventions improve fluid balance in fluid-restricted patients requiring parenteral nutrition. / Broyles, Joyce; Brown, Rex; Vehe, Kathryn L.; Nolly, Robert J.; Luther, R. Wayne.

In: Annals of Pharmacotherapy, Vol. 25, No. 2, 01.01.1991, p. 119-122.

Research output: Contribution to journalArticle

Broyles, Joyce ; Brown, Rex ; Vehe, Kathryn L. ; Nolly, Robert J. ; Luther, R. Wayne. / Pharmacist interventions improve fluid balance in fluid-restricted patients requiring parenteral nutrition. In: Annals of Pharmacotherapy. 1991 ; Vol. 25, No. 2. pp. 119-122.
@article{275f438772a446028d609de7cffa744d,
title = "Pharmacist interventions improve fluid balance in fluid-restricted patients requiring parenteral nutrition",
abstract = "Many intensive care unit (ICU) patients require parenteral nutrition (PN) and fluid restriction, making delivery of adequate nutrition difficult. We studied the effects of pharmacist interventions on fluid balance in fluid-restricted ICU patients requiring PN. Twenty patients were randomized to the treatment group (dextrose 70{\%} injection [D70W] plus 15{\%} amino acids for PN, 25-mL piggybacks, selected drugs added to the PN solution) or the control group (D70W plus 10{\%} amino acids, 50- or 100-mL piggybacks). Each group contained 10 patients and they were not significantly different for age, gender, weight, hospital days, and serum albumin concentration. The duration (9.3 ± 1.2 vs. 9.7 ± 2.4 d) and doses of PN (29 ± 6.8 vs. 28.7 ± 6.9 kcal/kg/d; 1.1 ± 0.3 vs. 1.1 ± 0.4 g/kg/d protein) were similar between treatment and control groups. Mean fluid intake (3112 ± 1146 vs. 3498 ± 1111 mL/d), fluid balance (146 ± 1581 vs. 708 ± 1402 mL/d), and cumulative fluid balance (1358 vs. 6867 mL) were all significantly lower in the treatment group. Mean fluid output was similar between the two groups. Pharmacist interventions can significantly decrease intake and result in a better fluid balance in fluid-restricted ICU patients who require PN.",
author = "Joyce Broyles and Rex Brown and Vehe, {Kathryn L.} and Nolly, {Robert J.} and Luther, {R. Wayne}",
year = "1991",
month = "1",
day = "1",
doi = "10.1177/106002809102500201",
language = "English (US)",
volume = "25",
pages = "119--122",
journal = "Annals of Pharmacotherapy",
issn = "1060-0280",
publisher = "Harvey Whitney Books Company",
number = "2",

}

TY - JOUR

T1 - Pharmacist interventions improve fluid balance in fluid-restricted patients requiring parenteral nutrition

AU - Broyles, Joyce

AU - Brown, Rex

AU - Vehe, Kathryn L.

AU - Nolly, Robert J.

AU - Luther, R. Wayne

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Many intensive care unit (ICU) patients require parenteral nutrition (PN) and fluid restriction, making delivery of adequate nutrition difficult. We studied the effects of pharmacist interventions on fluid balance in fluid-restricted ICU patients requiring PN. Twenty patients were randomized to the treatment group (dextrose 70% injection [D70W] plus 15% amino acids for PN, 25-mL piggybacks, selected drugs added to the PN solution) or the control group (D70W plus 10% amino acids, 50- or 100-mL piggybacks). Each group contained 10 patients and they were not significantly different for age, gender, weight, hospital days, and serum albumin concentration. The duration (9.3 ± 1.2 vs. 9.7 ± 2.4 d) and doses of PN (29 ± 6.8 vs. 28.7 ± 6.9 kcal/kg/d; 1.1 ± 0.3 vs. 1.1 ± 0.4 g/kg/d protein) were similar between treatment and control groups. Mean fluid intake (3112 ± 1146 vs. 3498 ± 1111 mL/d), fluid balance (146 ± 1581 vs. 708 ± 1402 mL/d), and cumulative fluid balance (1358 vs. 6867 mL) were all significantly lower in the treatment group. Mean fluid output was similar between the two groups. Pharmacist interventions can significantly decrease intake and result in a better fluid balance in fluid-restricted ICU patients who require PN.

AB - Many intensive care unit (ICU) patients require parenteral nutrition (PN) and fluid restriction, making delivery of adequate nutrition difficult. We studied the effects of pharmacist interventions on fluid balance in fluid-restricted ICU patients requiring PN. Twenty patients were randomized to the treatment group (dextrose 70% injection [D70W] plus 15% amino acids for PN, 25-mL piggybacks, selected drugs added to the PN solution) or the control group (D70W plus 10% amino acids, 50- or 100-mL piggybacks). Each group contained 10 patients and they were not significantly different for age, gender, weight, hospital days, and serum albumin concentration. The duration (9.3 ± 1.2 vs. 9.7 ± 2.4 d) and doses of PN (29 ± 6.8 vs. 28.7 ± 6.9 kcal/kg/d; 1.1 ± 0.3 vs. 1.1 ± 0.4 g/kg/d protein) were similar between treatment and control groups. Mean fluid intake (3112 ± 1146 vs. 3498 ± 1111 mL/d), fluid balance (146 ± 1581 vs. 708 ± 1402 mL/d), and cumulative fluid balance (1358 vs. 6867 mL) were all significantly lower in the treatment group. Mean fluid output was similar between the two groups. Pharmacist interventions can significantly decrease intake and result in a better fluid balance in fluid-restricted ICU patients who require PN.

UR - http://www.scopus.com/inward/record.url?scp=0025978834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025978834&partnerID=8YFLogxK

U2 - 10.1177/106002809102500201

DO - 10.1177/106002809102500201

M3 - Article

VL - 25

SP - 119

EP - 122

JO - Annals of Pharmacotherapy

JF - Annals of Pharmacotherapy

SN - 1060-0280

IS - 2

ER -