Pharmacogenetics of cocaine

I. Locomotor activity and self-selection

Byron Jones, Cheryl L. Reed, Richard A. Radcliffe, V. Gene Erwin

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We investigated the effects of cocaine on multiple activity measures and cocaine self-selection in C57BL/61bg†and DBA/2Ibg mice. Male mice were tested in an automated activity monitor at three doses of cocaine, 5,15 and 30 mg kg-1. Activity measures included locomotion, rearings, stereotyped movements and wall-seeking. Testing was conducted on 2 days with saline injection, i.p. on day one and cocaine i.p. injected on day two. We also tested other mice of both strains for cocaine ingestion in a two-choice test, pairing tap water with 40 mg% cocaine HC1 in tap water. Two separate groups of mice received 15 or 30 mg kg-1 of cocaine i.p., killed at 5 min and brain cocaine levels were determined by HPLC. Cocaine produced dose-related increases in locomotion in both strains, with a delay in initial activation noticed at 30 mg kg-1 in C57s but not in DBAs. In DBAs, cocaine suppressed rearings and increased stereotyped movements while having no consistent effect on either behaviour in C57s. At all doses, cocaine produced moderate increases in proximity to the wall in DBAs and 30 mg kg1 produced pronounced wall-seeking in C57s. At 15 and 30 mg kg-1 DBAs tended to have higher levels of cocaine in whole brain than did C57s. Finally, C57s consumed significantly more cocaine than did the DBAs.

Original languageEnglish (US)
Pages (from-to)182-188
Number of pages7
JournalPharmacogenetics
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Pharmacogenetics
Locomotion
Cocaine
Inbred DBA Mouse
Water
Brain
Eating
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Genetics
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Pharmacogenetics of cocaine : I. Locomotor activity and self-selection. / Jones, Byron; Reed, Cheryl L.; Radcliffe, Richard A.; Erwin, V. Gene.

In: Pharmacogenetics, Vol. 3, No. 4, 01.01.1993, p. 182-188.

Research output: Contribution to journalArticle

Jones, Byron ; Reed, Cheryl L. ; Radcliffe, Richard A. ; Erwin, V. Gene. / Pharmacogenetics of cocaine : I. Locomotor activity and self-selection. In: Pharmacogenetics. 1993 ; Vol. 3, No. 4. pp. 182-188.
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