Pharmacokinetic Changes in Critical Illness

Research output: Contribution to journalReview article

137 Citations (Scopus)

Abstract

Physiologic alterations in critically ill patients can significantly affect the pharmacokinetics of drugs used in the critically ill patient population. Understanding these pharmacokinetic changes is essential relative to optimizing drug therapy. This article outlines the major differences seen in the absorption, distribution, metabolism, and excretion of drugs in critically ill patients. Important strategies for drug therapy dosing and monitoring in these patients are also addressed.

Original languageEnglish (US)
Pages (from-to)255-271
Number of pages17
JournalCritical Care Clinics
Volume22
Issue number2
DOIs
StatePublished - Apr 1 2006

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Critical Illness
Pharmacokinetics
Drug Therapy
Drug Monitoring
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Pharmacokinetic Changes in Critical Illness. / Boucher, Bradley; Wood, G Christopher; Swanson, Joseph.

In: Critical Care Clinics, Vol. 22, No. 2, 01.04.2006, p. 255-271.

Research output: Contribution to journalReview article

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