Pharmacokinetic drug–drug interactions between immunosuppressant and anti-infective agents

Antimetabolites and corticosteroids

Edward Van Matre, Gowri Satyanarayana, Robert L. Page, Marilyn E. Levi, Joann Lindenfeld, Scott W. Mueller

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Infections account for 15–20% of deaths in transplant recipients, requiring rapid and appropriate therapeutic interventions. Many anti-infective agents interact with immunosuppressive regimens used in transplantation, placing patients at increased risk for adverse drug reactions and prolonged hospitalizations. There is established data regarding the level of evidence and magnitude of interactions between calcineurin inhibitors and mammalian target of rapamycin inhibitors with anti-infective agents. Less is known about the interactions with anti-proliferative agents and corticosteroids, with gaps in knowledge on the appropriate management of these interactions. The objective of this review was to highlight the pharmacokinetic drug–drug interactions between antimetabolites and corticosteroids with commonly used anti-infective agents.

Original languageEnglish (US)
Pages (from-to)66-74
Number of pages9
JournalAnnals of Transplantation
Volume23
DOIs
StatePublished - Jan 1 2018

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Antimetabolites
Immunosuppressive Agents
Anti-Infective Agents
Adrenal Cortex Hormones
Pharmacokinetics
Sirolimus
Drug-Related Side Effects and Adverse Reactions
Hospitalization
Transplantation
Infection
Therapeutics

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Pharmacokinetic drug–drug interactions between immunosuppressant and anti-infective agents : Antimetabolites and corticosteroids. / Van Matre, Edward; Satyanarayana, Gowri; Page, Robert L.; Levi, Marilyn E.; Lindenfeld, Joann; Mueller, Scott W.

In: Annals of Transplantation, Vol. 23, 01.01.2018, p. 66-74.

Research output: Contribution to journalReview article

Van Matre, Edward ; Satyanarayana, Gowri ; Page, Robert L. ; Levi, Marilyn E. ; Lindenfeld, Joann ; Mueller, Scott W. / Pharmacokinetic drug–drug interactions between immunosuppressant and anti-infective agents : Antimetabolites and corticosteroids. In: Annals of Transplantation. 2018 ; Vol. 23. pp. 66-74.
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