Pharmacokinetics and pharmacodynamics of inhaled corticosteroids

H. Derendorf, G. Hochhaus, Bernd Meibohm, H. Möllmann, J. Barth

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

There are significant differences in the pharmacokinetic properties of inhaled corticosteroids currently used in medical practice. All are rapidly cleared from the body but they show varying levels of oral bioavailability and more importantly variation in the rate of absorption after inhalation. Oral bioavailability is lowest for fluticasone propionate, indicating a low potential for unwanted systemic corticosteroid effects. Mathematical modeling has shown pulmonary residence times to be longest for fluticasone propionate and triamcinolone acetonide but shortest for budesonide and flunisolide. These properties appear to relate to pulmonary solubility, which appears to be the rate-limiting step in the absorption process.

Original languageEnglish (US)
JournalJournal of Allergy and Clinical Immunology
Volume101
Issue number4 SUPPL.
StatePublished - Dec 1 1998

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flunisolide
Biological Availability
Adrenal Cortex Hormones
Pharmacokinetics
Triamcinolone Acetonide
Budesonide
Lung
Solubility
Inhalation
Fluticasone

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Derendorf, H., Hochhaus, G., Meibohm, B., Möllmann, H., & Barth, J. (1998). Pharmacokinetics and pharmacodynamics of inhaled corticosteroids. Journal of Allergy and Clinical Immunology, 101(4 SUPPL.).

Pharmacokinetics and pharmacodynamics of inhaled corticosteroids. / Derendorf, H.; Hochhaus, G.; Meibohm, Bernd; Möllmann, H.; Barth, J.

In: Journal of Allergy and Clinical Immunology, Vol. 101, No. 4 SUPPL., 01.12.1998.

Research output: Contribution to journalArticle

Derendorf, H, Hochhaus, G, Meibohm, B, Möllmann, H & Barth, J 1998, 'Pharmacokinetics and pharmacodynamics of inhaled corticosteroids', Journal of Allergy and Clinical Immunology, vol. 101, no. 4 SUPPL..
Derendorf, H. ; Hochhaus, G. ; Meibohm, Bernd ; Möllmann, H. ; Barth, J. / Pharmacokinetics and pharmacodynamics of inhaled corticosteroids. In: Journal of Allergy and Clinical Immunology. 1998 ; Vol. 101, No. 4 SUPPL.
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