Pharmacokinetics and pharmacodynamics of peptide and protein therapeutics

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

The rational use of drugs and the design of effective dosage regimens are facilitated by the appreciation of the central paradigm of clinical pharmacology that there is a defined relationship between the administered dose of a drug, the resulting drug concentrations in various body fluids and tissues, and the intensity of pharmacologic effects caused by these concentrations (Meibohm and Derendorf 1997). This dose-exposure-response relationship and thus the dose of a drug required to achieve a certain effect are determined by the drug’s pharmacokinetic and pharmacodynamic properties (Fig. 5.1).

Original languageEnglish (US)
Title of host publicationPharmaceutical Biotechnology
Subtitle of host publicationFundamentals and Applications, Fourth Edition
PublisherSpringer New York
Pages101-132
Number of pages32
ISBN (Electronic)9781461464860
ISBN (Print)9781461464853
DOIs
StatePublished - Jan 1 2013

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Pharmacokinetics
Peptides
Pharmaceutical Preparations
Proteins
Clinical Pharmacology
Drug Design
Body Fluids
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Meibohm, B. (2013). Pharmacokinetics and pharmacodynamics of peptide and protein therapeutics. In Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition (pp. 101-132). Springer New York. https://doi.org/10.1007/978-1-4614-6486-0_5

Pharmacokinetics and pharmacodynamics of peptide and protein therapeutics. / Meibohm, Bernd.

Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition. Springer New York, 2013. p. 101-132.

Research output: Chapter in Book/Report/Conference proceedingChapter

Meibohm, B 2013, Pharmacokinetics and pharmacodynamics of peptide and protein therapeutics. in Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition. Springer New York, pp. 101-132. https://doi.org/10.1007/978-1-4614-6486-0_5
Meibohm B. Pharmacokinetics and pharmacodynamics of peptide and protein therapeutics. In Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition. Springer New York. 2013. p. 101-132 https://doi.org/10.1007/978-1-4614-6486-0_5
Meibohm, Bernd. / Pharmacokinetics and pharmacodynamics of peptide and protein therapeutics. Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition. Springer New York, 2013. pp. 101-132
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