Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose

Steven Laizure, C. Lindsay DeVane, Jonathan T. Stewart, Cynthia S. Dommisse, Allen A. Lai

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The pharmacokinetics of bupropion (BUP) and its three major basic metabolites (the erythroamino alcohol [EB], the threoamino alcohol [TB], and the hydroxy [HB] metabolites) were characterized after a single, oral, 200 mg dose of BUP in six healthy men. Twenty-one sequential plasma samples for analysis by HPLC were drawn from each subject over the 56-hour period after dosing. Pharmacokinetic analyses were by noncompartmental methods. The mean elimination t 1 2 values of BUP, TB, EB, and HB were 9.8, 19.8, 26.8, and 22.2 hours, respectively. The mean plasma AUCs of TB and HB were 2.4 and 10.3 times greater, respectively, than that for BUP. Because of the substantial presence of these metabolites in systemic circulation, further studies are recommended to understand further their roles in the clinical profile of this new antidepressant.

Original languageEnglish (US)
Pages (from-to)586-589
Number of pages4
JournalClinical Pharmacology and Therapeutics
Volume38
Issue number5
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Bupropion
Pharmacokinetics
Alcohols
Antidepressive Agents
Area Under Curve
High Pressure Liquid Chromatography

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose. / Laizure, Steven; Lindsay DeVane, C.; Stewart, Jonathan T.; Dommisse, Cynthia S.; Lai, Allen A.

In: Clinical Pharmacology and Therapeutics, Vol. 38, No. 5, 01.01.1985, p. 586-589.

Research output: Contribution to journalArticle

Laizure, Steven ; Lindsay DeVane, C. ; Stewart, Jonathan T. ; Dommisse, Cynthia S. ; Lai, Allen A. / Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose. In: Clinical Pharmacology and Therapeutics. 1985 ; Vol. 38, No. 5. pp. 586-589.
@article{e049665843324a6eb8c54ecb41d065fb,
title = "Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose",
abstract = "The pharmacokinetics of bupropion (BUP) and its three major basic metabolites (the erythroamino alcohol [EB], the threoamino alcohol [TB], and the hydroxy [HB] metabolites) were characterized after a single, oral, 200 mg dose of BUP in six healthy men. Twenty-one sequential plasma samples for analysis by HPLC were drawn from each subject over the 56-hour period after dosing. Pharmacokinetic analyses were by noncompartmental methods. The mean elimination t 1 2 values of BUP, TB, EB, and HB were 9.8, 19.8, 26.8, and 22.2 hours, respectively. The mean plasma AUCs of TB and HB were 2.4 and 10.3 times greater, respectively, than that for BUP. Because of the substantial presence of these metabolites in systemic circulation, further studies are recommended to understand further their roles in the clinical profile of this new antidepressant.",
author = "Steven Laizure and {Lindsay DeVane}, C. and Stewart, {Jonathan T.} and Dommisse, {Cynthia S.} and Lai, {Allen A.}",
year = "1985",
month = "1",
day = "1",
language = "English (US)",
volume = "38",
pages = "586--589",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose

AU - Laizure, Steven

AU - Lindsay DeVane, C.

AU - Stewart, Jonathan T.

AU - Dommisse, Cynthia S.

AU - Lai, Allen A.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - The pharmacokinetics of bupropion (BUP) and its three major basic metabolites (the erythroamino alcohol [EB], the threoamino alcohol [TB], and the hydroxy [HB] metabolites) were characterized after a single, oral, 200 mg dose of BUP in six healthy men. Twenty-one sequential plasma samples for analysis by HPLC were drawn from each subject over the 56-hour period after dosing. Pharmacokinetic analyses were by noncompartmental methods. The mean elimination t 1 2 values of BUP, TB, EB, and HB were 9.8, 19.8, 26.8, and 22.2 hours, respectively. The mean plasma AUCs of TB and HB were 2.4 and 10.3 times greater, respectively, than that for BUP. Because of the substantial presence of these metabolites in systemic circulation, further studies are recommended to understand further their roles in the clinical profile of this new antidepressant.

AB - The pharmacokinetics of bupropion (BUP) and its three major basic metabolites (the erythroamino alcohol [EB], the threoamino alcohol [TB], and the hydroxy [HB] metabolites) were characterized after a single, oral, 200 mg dose of BUP in six healthy men. Twenty-one sequential plasma samples for analysis by HPLC were drawn from each subject over the 56-hour period after dosing. Pharmacokinetic analyses were by noncompartmental methods. The mean elimination t 1 2 values of BUP, TB, EB, and HB were 9.8, 19.8, 26.8, and 22.2 hours, respectively. The mean plasma AUCs of TB and HB were 2.4 and 10.3 times greater, respectively, than that for BUP. Because of the substantial presence of these metabolites in systemic circulation, further studies are recommended to understand further their roles in the clinical profile of this new antidepressant.

UR - http://www.scopus.com/inward/record.url?scp=0022344462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022344462&partnerID=8YFLogxK

M3 - Article

VL - 38

SP - 586

EP - 589

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 5

ER -