Pharmacokinetics of ponazuril after oral administration to healthy llamas (Lama glama)

Maria E. Prado, Josiah T. Ryman, Melanie J. Boileau, Tomas Martin-Jimenez, Bernd Meibohm

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective-To determine the pharmacokinetics after oral administration of a single dose of ponazuril to healthy llamas. Animals-6 healthy adult llamas. Procedures-Ponazuril (20 mg/kg) was administered once orally to 6 llamas (day 0). Blood samples were obtained on days 0, 0.5, 1, 2, 3, 4, 5, 6, 7, 9, 11, 14, 21, 28, 35, 42, and 49. Serum ponazuril concentrations were determined by use of a validated reverse-phase high-performance liquid chromatography assay with UV absorbance detection. Pharmacokinetic parameters were derived by use of a standard noncompartmental pharmacokinetic analysis. Results-Mean ± SD area under the serum concentration-time curve was 7,516 ± 2,750 h•mg/L, maximum serum ponazuril concentration was 23.6 ± 6.0 mg/L, and the elimination half-life was 135.5 ± 16.7 hours. Serum concentration of ponazuril peaked at 84 hours (range, 48 to 120 hours) after administration and gradually decreased but remained detectable for up to 35 days after administration. No adverse effects were observed during the study period. Conclusions and Clinical Relevance-The rate and extent of absorption following oral administration of a single dose of ponazuril were sufficient to result in potentially effective concentrations, and the drug was tolerated well by llamas. At this dose, ponazuril resulted in serum concentrations that were high enough to be effective against various Apicomplexans on the basis of data for other species. The effective ponazuril concentration that will induce 50% inhibition of parasite growth for Eimeria macusaniensis in camelids is currently unknown.

Original languageEnglish (US)
Pages (from-to)1386-1389
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume72
Issue number10
DOIs
StatePublished - Oct 1 2011

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New World Camelids
llamas
blood serum
oral administration
pharmacokinetics
Oral Administration
Pharmacokinetics
Serum
dosage
Camelidae
reversed-phase liquid chromatography
Eimeria
absorbance
half life
high performance liquid chromatography
adverse effects
ponazuril
Reverse-Phase Chromatography
parasites
drugs

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Pharmacokinetics of ponazuril after oral administration to healthy llamas (Lama glama). / Prado, Maria E.; Ryman, Josiah T.; Boileau, Melanie J.; Martin-Jimenez, Tomas; Meibohm, Bernd.

In: American Journal of Veterinary Research, Vol. 72, No. 10, 01.10.2011, p. 1386-1389.

Research output: Contribution to journalArticle

Prado, Maria E. ; Ryman, Josiah T. ; Boileau, Melanie J. ; Martin-Jimenez, Tomas ; Meibohm, Bernd. / Pharmacokinetics of ponazuril after oral administration to healthy llamas (Lama glama). In: American Journal of Veterinary Research. 2011 ; Vol. 72, No. 10. pp. 1386-1389.
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