Pharmacological caspase inhibitors

Research towards therapeutic perspectives

J. Kudelova, J. Fleischmannova, E. Adamova, E. Matalova

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Caspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications.

Original languageEnglish (US)
Pages (from-to)473-482
Number of pages10
JournalJournal of Physiology and Pharmacology
Volume66
Issue number4
StatePublished - Jan 1 2015

Fingerprint

Therapeutic Human Experimentation
Caspase Inhibitors
Caspases
Pharmacology
Apoptosis
Animal Disease Models
Immune System Diseases
Neurodegenerative Diseases
Cell Death
Up-Regulation
Therapeutics
Pathology
Inflammation
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology

Cite this

Pharmacological caspase inhibitors : Research towards therapeutic perspectives. / Kudelova, J.; Fleischmannova, J.; Adamova, E.; Matalova, E.

In: Journal of Physiology and Pharmacology, Vol. 66, No. 4, 01.01.2015, p. 473-482.

Research output: Contribution to journalReview article

Kudelova, J, Fleischmannova, J, Adamova, E & Matalova, E 2015, 'Pharmacological caspase inhibitors: Research towards therapeutic perspectives', Journal of Physiology and Pharmacology, vol. 66, no. 4, pp. 473-482.
Kudelova, J. ; Fleischmannova, J. ; Adamova, E. ; Matalova, E. / Pharmacological caspase inhibitors : Research towards therapeutic perspectives. In: Journal of Physiology and Pharmacology. 2015 ; Vol. 66, No. 4. pp. 473-482.
@article{fdcf3626b932411288d351a9b0915781,
title = "Pharmacological caspase inhibitors: Research towards therapeutic perspectives",
abstract = "Caspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications.",
author = "J. Kudelova and J. Fleischmannova and E. Adamova and E. Matalova",
year = "2015",
month = "1",
day = "1",
language = "English (US)",
volume = "66",
pages = "473--482",
journal = "Journal of Physiology and Pharmacology",
issn = "0867-5910",
publisher = "Polish Physiological Society",
number = "4",

}

TY - JOUR

T1 - Pharmacological caspase inhibitors

T2 - Research towards therapeutic perspectives

AU - Kudelova, J.

AU - Fleischmannova, J.

AU - Adamova, E.

AU - Matalova, E.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Caspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications.

AB - Caspases are key molecules of apoptosis and the inflammatory response. Up-regulation of the caspase cascade contributes to human pathologies such as neurodegenerative and immune disorders. Thus, blocking the excessive apoptosis by pharmacological inhibitors seems promising for therapeutic interventions in such diseases. Caspase inhibitors, both natural and artificial, have been used as research tools and have helped to define the role of the individual caspases in apoptosis and in non-apoptotic processes. Moreover, some caspase inhibitors have demonstrated their therapeutic efficiency in the reduction of cell death and inflammation in animal models of human diseases. However, no drug based on caspase inhibition has been approved on the market until now. Thus, the development of therapeutic approaches that specifically target caspases remains a great challenge and is now the focus of intense biological and clinical interest. Here, we provide a brief review of recent knowledge about pharmacological caspase inhibitors with special focus on their proposed clinical applications.

UR - http://www.scopus.com/inward/record.url?scp=84940744287&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940744287&partnerID=8YFLogxK

M3 - Review article

VL - 66

SP - 473

EP - 482

JO - Journal of Physiology and Pharmacology

JF - Journal of Physiology and Pharmacology

SN - 0867-5910

IS - 4

ER -