Phenocopy of warfarin syndrome in an infant born to a mother with sickle cell anemia and severe transfusional iron overload

Yi Xie, Eniko K. Pivnick, Harris Cohen, Patricia Adams-Graves, Massroor Pourcyrous, Banu Aygun, Jane S. Hankins

Research output: Contribution to journalArticle

Abstract

Neonatal chondrodysplasia punctata (CDP) is characterized by epiphyseal stippling and midfacial hypoplasia. CDP is usually inherited, but can be acquired because of maternal vitamin K deficiency. We describe an infant with CDP born to a teenager with sickle cell anemia and transfusional iron overload. The mother had severe liver fibrosis, elevated liver iron concentration (34 mg Fe/g), and coagulopathy, but no gestational use of warfarin. Fetal abnormalities were attributed to vitamin K deficiency secondary to liver dysfunction from iron toxicity. Treatment of iron overload among women with sickle cell anemia of childbearing potential is important to avoid possible CDP in newborns.

Original languageEnglish (US)
JournalJournal of pediatric hematology/oncology
Volume35
Issue number6
DOIs
StatePublished - Aug 1 2013

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Chondrodysplasia Punctata
Iron Overload
Sickle Cell Anemia
Vitamin K Deficiency
Mothers
Iron
Warfarin
Liver Cirrhosis
Liver Diseases
Newborn Infant
Warfarin syndrome
Liver

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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abstract = "Neonatal chondrodysplasia punctata (CDP) is characterized by epiphyseal stippling and midfacial hypoplasia. CDP is usually inherited, but can be acquired because of maternal vitamin K deficiency. We describe an infant with CDP born to a teenager with sickle cell anemia and transfusional iron overload. The mother had severe liver fibrosis, elevated liver iron concentration (34 mg Fe/g), and coagulopathy, but no gestational use of warfarin. Fetal abnormalities were attributed to vitamin K deficiency secondary to liver dysfunction from iron toxicity. Treatment of iron overload among women with sickle cell anemia of childbearing potential is important to avoid possible CDP in newborns.",
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T1 - Phenocopy of warfarin syndrome in an infant born to a mother with sickle cell anemia and severe transfusional iron overload

AU - Xie, Yi

AU - Pivnick, Eniko K.

AU - Cohen, Harris

AU - Adams-Graves, Patricia

AU - Pourcyrous, Massroor

AU - Aygun, Banu

AU - Hankins, Jane S.

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AB - Neonatal chondrodysplasia punctata (CDP) is characterized by epiphyseal stippling and midfacial hypoplasia. CDP is usually inherited, but can be acquired because of maternal vitamin K deficiency. We describe an infant with CDP born to a teenager with sickle cell anemia and transfusional iron overload. The mother had severe liver fibrosis, elevated liver iron concentration (34 mg Fe/g), and coagulopathy, but no gestational use of warfarin. Fetal abnormalities were attributed to vitamin K deficiency secondary to liver dysfunction from iron toxicity. Treatment of iron overload among women with sickle cell anemia of childbearing potential is important to avoid possible CDP in newborns.

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