Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice

Dabney K. Johnson, Eugene M. Rinchik, Naima Moustaid-Moussa, Darla R. Miller, Robert Williams, Edward J. Michaud, Monica Jablonski, Andrea Elberger, Kristin Hamre, Richard Smeyne, Elissa Chesler, Daniel Goldowitz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.

Original languageEnglish (US)
Pages (from-to)75-90
Number of pages16
JournalAge
Volume27
Issue number1
DOIs
StatePublished - Mar 1 2005

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Ethylnitrosourea
Age of Onset
Phenotype
Nervous System Diseases
Genes
Mammals
Mutation
Growth

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

Johnson, D. K., Rinchik, E. M., Moustaid-Moussa, N., Miller, D. R., Williams, R., Michaud, E. J., ... Goldowitz, D. (2005). Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. Age, 27(1), 75-90. https://doi.org/10.1007/s11357-005-4131-3

Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. / Johnson, Dabney K.; Rinchik, Eugene M.; Moustaid-Moussa, Naima; Miller, Darla R.; Williams, Robert; Michaud, Edward J.; Jablonski, Monica; Elberger, Andrea; Hamre, Kristin; Smeyne, Richard; Chesler, Elissa; Goldowitz, Daniel.

In: Age, Vol. 27, No. 1, 01.03.2005, p. 75-90.

Research output: Contribution to journalArticle

Johnson, DK, Rinchik, EM, Moustaid-Moussa, N, Miller, DR, Williams, R, Michaud, EJ, Jablonski, M, Elberger, A, Hamre, K, Smeyne, R, Chesler, E & Goldowitz, D 2005, 'Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice', Age, vol. 27, no. 1, pp. 75-90. https://doi.org/10.1007/s11357-005-4131-3
Johnson, Dabney K. ; Rinchik, Eugene M. ; Moustaid-Moussa, Naima ; Miller, Darla R. ; Williams, Robert ; Michaud, Edward J. ; Jablonski, Monica ; Elberger, Andrea ; Hamre, Kristin ; Smeyne, Richard ; Chesler, Elissa ; Goldowitz, Daniel. / Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice. In: Age. 2005 ; Vol. 27, No. 1. pp. 75-90.
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