Phenotypic identification of mononuclear cells in oral premalignant lesions and cancer by monoclonal antibodies

Cesar Migliorati, E. K.J. Migliorati, S. Silverman, D. Greenspan, J. S. Greenspan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To explore the nature and importance of mononuclear cells of different phenotypes in oral premalignant lesions and oral cancer, we studied biopsy specimens from 21 oral red and/or white lesions (6 hyperkeratosis, 3 mild dysplasia, 4 severe dysplasia and 8 squamous cell carcinoma), using monoclonal antibodies and avidin‐biotin‐peroxidase complex staining. Peripheral blood samples (J'B) from 4 normal subjects and 5 reactive lymph nodes (LN) were used as controls for the technique. T11‐positive cells were the predominant phenotype (74–78%) in all cases examined. The T4/T8 ratio in severe dysplasia was significantly lower than that in mild dysplasia (p ≤. 0.05). These observations support the hypothesis of a role for cellular immune responses in oral premalignant lesions and oral cancer. The predominance of T cells may represent the local expression of immunity against antigens (viral or other). The decreased T4/T8 ratio observed in severe dysplasia may represent a transitory stage of local immunosuppression, which may be of critical importance for the progression into carcinoma. Phenotypic variations in mononuclear cell infiltrates in these conditions could be of diagnostic value.

Original languageEnglish (US)
Pages (from-to)352-358
Number of pages7
JournalJournal of Oral Pathology & Medicine
Volume15
Issue number6
DOIs
StatePublished - Jan 1 1986

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CD4-CD8 Ratio
Mouth Neoplasms
Monoclonal Antibodies
Phenotype
Neoplasms
Viral Antigens
Cellular Immunity
Immunosuppression
Squamous Cell Carcinoma
Immunity
Lymph Nodes
Staining and Labeling
Carcinoma
T-Lymphocytes
Biopsy

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

Phenotypic identification of mononuclear cells in oral premalignant lesions and cancer by monoclonal antibodies. / Migliorati, Cesar; Migliorati, E. K.J.; Silverman, S.; Greenspan, D.; Greenspan, J. S.

In: Journal of Oral Pathology & Medicine, Vol. 15, No. 6, 01.01.1986, p. 352-358.

Research output: Contribution to journalArticle

Migliorati, Cesar ; Migliorati, E. K.J. ; Silverman, S. ; Greenspan, D. ; Greenspan, J. S. / Phenotypic identification of mononuclear cells in oral premalignant lesions and cancer by monoclonal antibodies. In: Journal of Oral Pathology & Medicine. 1986 ; Vol. 15, No. 6. pp. 352-358.
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