Phenylthiocarbamide produces conditioned taste aversions in mice

S. J St John, Lindsay Pour, John Boughter

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Previous work has demonstrated that SWR/J (SW) mice avoid phenylthiocarbamide (PTC) to a greater degree than C3HeB/FeJ mice in 48 h, two-bottle preference tests given in ascending series. The authors hypothesized, based also on previous work, that SW mice might form a conditioned taste aversion over time due to the toxic properties of PTC. We directly tested this hypothesis by attempting to condition a taste aversion to sucrose by injections of PTC. In experiment 1, PTC was nearly as effective as a strong dose of LiCl in reducing sucrose drinking. In experiment 2, the sucrose aversions were parametrically modified by both sucrose concentration and PTC dose, a hallmark of conditioned taste aversion. We conclude that PTC can cause a conditioned taste aversion and discuss the importance of considering toxic effects of aversive tastants when analyzing behavioral strain differences.

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalChemical senses
Volume30
Issue number5
DOIs
StatePublished - Jun 1 2005

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Phenylthiourea
sucrose
Sucrose
mice
Poisons
strain differences
dosage
drinking
bottles
injection
Drinking
Injections
testing

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences (miscellaneous)
  • Food Science
  • Physiology
  • Physiology (medical)
  • Neuroscience(all)
  • Behavioral Neuroscience

Cite this

Phenylthiocarbamide produces conditioned taste aversions in mice. / John, S. J St ; Pour, Lindsay; Boughter, John.

In: Chemical senses, Vol. 30, No. 5, 01.06.2005, p. 377-382.

Research output: Contribution to journalArticle

John, S. J St ; Pour, Lindsay ; Boughter, John. / Phenylthiocarbamide produces conditioned taste aversions in mice. In: Chemical senses. 2005 ; Vol. 30, No. 5. pp. 377-382.
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