Phosphodiesterase inhibition and lipolytic action of the stereoisomers of trimetoquinol

M. T. Piascik, Duane Miller, D. R. Feller

Research output: Contribution to journalArticle

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Abstract

The isomers and racemate of trimetoquinol [TMQ; 6 7 dihydroxy 1 (3',4',5' trimethoxybenzyl) 1,2,3,4 tetrahydroisoquinoline] as well as N (3',4',5' trimethoxyphenethyl) dopamine were all shown to be effective at promoting glycerol release from rat epididymal fat tissue. The rank order of potency observed for these compounds was (-) TMQ ≥ (±) TMQ >> (+) TMQ = N (3 trimethoxyphenethyl) dopamine. (±) TMQ and (-) TMQ were the only agents capable of producing a maximal lipolytic response. None of the compounds tested were able to exhibit significant c AMP phosphodiesterase inhibition. This study is the first report which shows that the β adrenoceptor activity of the isomers of TMQ does not correlate with an inhibition of c AMP phosphodiesterase. An alternate mechanism of action for these compounds is proposed.

Original languageEnglish (US)
Pages (from-to)203-215
Number of pages13
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume13
Issue number2
StatePublished - Dec 1 1976
Externally publishedYes

Fingerprint

Stereoisomerism
Phosphoric Diester Hydrolases
Adenosine Monophosphate
Isomers
Glycerol
Adrenergic Receptors
Rats
Dopamine
Fats
Tissue
1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
6-(4-hydroxybutyl)-2,3,5-trimethyl-1,4-benzoquinone
N-(3',4',5'-trimethoxyphenethyl)dopamine

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Phosphodiesterase inhibition and lipolytic action of the stereoisomers of trimetoquinol. / Piascik, M. T.; Miller, Duane; Feller, D. R.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 13, No. 2, 01.12.1976, p. 203-215.

Research output: Contribution to journalArticle

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