Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor

M. W. Marino, L. J. Feld, E. A. Jaffe, Lawrence Pfeffer, H. M. Han, D. B. Donner

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The initiation of mRNA translation is regulated by the reversible phosphorylation of several initiation factors. We report here that tumor necrosis factor-α (TNF) rapidly stimulates phosphorylation of one such factor, an mRNA cap binding protein, in several cell types which are important in vitro models of TNF action. This protein has been purified, sequenced, and identified as the proto-oncogene product eukaryotic initiation factor 4E. These data show that phosphorylation of a key component of the cellular translational machinery is a common early event in the various actions of TNF in diverse cell types.

Original languageEnglish (US)
Pages (from-to)2685-2688
Number of pages4
JournalJournal of Biological Chemistry
Volume266
Issue number5
StatePublished - Jul 10 1991
Externally publishedYes

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Eukaryotic Initiation Factor-4E
Phosphorylation
Proto-Oncogenes
Oncogene Proteins
Tumor Necrosis Factor-alpha
RNA Cap-Binding Proteins
Peptide Initiation Factors
Protein Biosynthesis
Machinery
Messenger RNA
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor. / Marino, M. W.; Feld, L. J.; Jaffe, E. A.; Pfeffer, Lawrence; Han, H. M.; Donner, D. B.

In: Journal of Biological Chemistry, Vol. 266, No. 5, 10.07.1991, p. 2685-2688.

Research output: Contribution to journalArticle

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