Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation

N. D. Cosgrove, A. M. Al-Osaimi, H. K. Sanoff, M. M. Morris, P. W. Read, D. G. Cox, J. A. Mann, C. K. Argo, C. L. Berg, S. J. Pelletier, Daniel Maluf, A. Y. Wang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Many transplant centers use endoscopically directed brachytherapy to provide locoregional control in patients with otherwise incurable cholangiocarcinoma (CCA) who are awaiting liver transplantation (LT). The use of endoscopic retrograde cholangiopancreatography (ERCP)-directed photodynamic therapy (PDT) as an alternative to brachytherapy for providing locoregional control in this patient population has not been studied. The aim of this study was to report on our initial experience using ERCP-directed PDT to provide local control in patients with unresectable CCA who were awaiting LT. Patients with unresectable CCA who underwent protocol-driven neoadjuvant chemoradiation and ERCP-directed PDT with the intent of undergoing LT were reviewed. Four patients with confirmed or suspected CCA met the inclusion criteria for protocol LT. All four patients (100%) successfully underwent ERCP-directed PDT. All patients had chemoradiation dose delays, and two patients had recurrent cholangitis despite PDT. None of these patients had progressive locoregional disease or distant metastasis following PDT. All four patients (100%) underwent LT. Intention-to-treat disease-free survival was 75% at mean follow-up of 28.1 months. In summary, ERCP-directed PDT is a reasonably well tolerated and safe procedure that may have benefit by maintaining locoregional tumor control in patients with CCA who are awaiting LT. Photodynamic therapy is a reasonably well tolerated and safe endoscopic ablation technique that may maintain locoregional tumor control in patients with cholangiocarcinoma who are awaiting liver transplantation.

Original languageEnglish (US)
Pages (from-to)466-471
Number of pages6
JournalAmerican Journal of Transplantation
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

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Cholangiocarcinoma
Photochemotherapy
Liver Transplantation
Endoscopic Retrograde Cholangiopancreatography
Brachytherapy
Ablation Techniques
Cholangitis
Disease-Free Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Cosgrove, N. D., Al-Osaimi, A. M., Sanoff, H. K., Morris, M. M., Read, P. W., Cox, D. G., ... Wang, A. Y. (2014). Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation. American Journal of Transplantation, 14(2), 466-471. https://doi.org/10.1111/ajt.12597

Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation. / Cosgrove, N. D.; Al-Osaimi, A. M.; Sanoff, H. K.; Morris, M. M.; Read, P. W.; Cox, D. G.; Mann, J. A.; Argo, C. K.; Berg, C. L.; Pelletier, S. J.; Maluf, Daniel; Wang, A. Y.

In: American Journal of Transplantation, Vol. 14, No. 2, 01.02.2014, p. 466-471.

Research output: Contribution to journalArticle

Cosgrove, ND, Al-Osaimi, AM, Sanoff, HK, Morris, MM, Read, PW, Cox, DG, Mann, JA, Argo, CK, Berg, CL, Pelletier, SJ, Maluf, D & Wang, AY 2014, 'Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation', American Journal of Transplantation, vol. 14, no. 2, pp. 466-471. https://doi.org/10.1111/ajt.12597
Cosgrove, N. D. ; Al-Osaimi, A. M. ; Sanoff, H. K. ; Morris, M. M. ; Read, P. W. ; Cox, D. G. ; Mann, J. A. ; Argo, C. K. ; Berg, C. L. ; Pelletier, S. J. ; Maluf, Daniel ; Wang, A. Y. / Photodynamic therapy provides local control of cholangiocarcinoma in patients awaiting liver transplantation. In: American Journal of Transplantation. 2014 ; Vol. 14, No. 2. pp. 466-471.
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AU - Read, P. W.

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