Physical activity, body size, and estrogen metabolism in women

Charles E. Matthews, Jay Fowke, Qi Dai, H. Leon Bradlow, Fan Jin, Xiao Ou Shu, Yu Tang Gao, Christopher Longcope, James R. Hebert, Wei Zheng

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objectives: Physical activity has demonstrable effects on estrogen levels in pre- and postmenopausal women. Increased oxidation of estrone to 2-hydroxyestrone (2HE) relative to 16α-hydroxyestrone (16HE) has been hypothesized to reduce breast cancer risk, but little is known about the effect of physical activity and body size in relation to the ratio of 2HE and 16HE in women. We examined these relationships in cross-sectional analyses of 157 North American and Chinese women. Methods: Physical activity was assessed using validated questionnaires. Adiposity was assessed as body mass index (BMI, kg/m 2) and by anthropometric methods (% body fat). Estrone metabolites, 2HE and 16HE, were determined from urine via ELISA. Results: Regression analyses on the 2HE/16HE ratio revealed an interaction between leisure-time physical activities and adiposity in both North American and Chinese women (p ≤ 0.05). Women reporting low levels of leisure-time physical activity who had higher BMI levels had 2HE/16HE ratios that were lower than their lean counterparts. In contrast, women with higher BMI levels that were physically active maintained higher 2HE/16HE ratios. Conclusion: These findings suggest that physical activity participation has the potential to modify the adverse effect of increased adiposity on estrogen metabolism in North American and Chinese women.

Original languageEnglish (US)
Pages (from-to)473-481
Number of pages9
JournalCancer Causes and Control
Volume15
Issue number5
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

Fingerprint

Body Size
Estrogens
Exercise
Adiposity
Estrone
Leisure Activities
2-hydroxyestrone
16-hydroxyestrone
Adipose Tissue
Body Mass Index
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Urine
Breast Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Matthews, C. E., Fowke, J., Dai, Q., Leon Bradlow, H., Jin, F., Shu, X. O., ... Zheng, W. (2004). Physical activity, body size, and estrogen metabolism in women. Cancer Causes and Control, 15(5), 473-481. https://doi.org/10.1023/B:CACO.0000036445.04238.87

Physical activity, body size, and estrogen metabolism in women. / Matthews, Charles E.; Fowke, Jay; Dai, Qi; Leon Bradlow, H.; Jin, Fan; Shu, Xiao Ou; Gao, Yu Tang; Longcope, Christopher; Hebert, James R.; Zheng, Wei.

In: Cancer Causes and Control, Vol. 15, No. 5, 01.06.2004, p. 473-481.

Research output: Contribution to journalArticle

Matthews, CE, Fowke, J, Dai, Q, Leon Bradlow, H, Jin, F, Shu, XO, Gao, YT, Longcope, C, Hebert, JR & Zheng, W 2004, 'Physical activity, body size, and estrogen metabolism in women', Cancer Causes and Control, vol. 15, no. 5, pp. 473-481. https://doi.org/10.1023/B:CACO.0000036445.04238.87
Matthews, Charles E. ; Fowke, Jay ; Dai, Qi ; Leon Bradlow, H. ; Jin, Fan ; Shu, Xiao Ou ; Gao, Yu Tang ; Longcope, Christopher ; Hebert, James R. ; Zheng, Wei. / Physical activity, body size, and estrogen metabolism in women. In: Cancer Causes and Control. 2004 ; Vol. 15, No. 5. pp. 473-481.
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