Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes

The look AHEAD study

Denise K. Houston, Rebecca H. Neiberg, Michael E. Miller, James O. Hill, John M. Jakicic, Karen Johnson, Edward W. Gregg, Van S. Hubbard, Xavier Pi-Sunyer, W. Jack Rejeski, Rena R. Wing, John P. Bantle, Elizabeth Beale, Robert I. Berkowitz, Maria Cassidy-Begay, Jeanne M. Clark, Mathilda Coday, Linda M. Delahanty, Gareth Dutton, Caitlin Egan & 24 others John P. Foreyt, Frank L. Greenway, Helen P. Hazuda, Andrea Hergenroeder, Edward S. Horton, Robert W. Jeffery, Steven E. Kahn, Anne Kure, William C. Knowler, Cora E. Lewis, Corby K. Martin, Sara Michaels, Maria G. Montez, David M. Nathan, Jennifer Patricio, Anne Peters, Henry Pownall, Judith Regensteiner, Helmut Steinburg, Thomas A. Wadden, Karen White, Susan Z. Yanovski, Ping Zhang, Stephen B. Kritchevsky

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods Overweight and obese (body mass index ≥ 25 kg/m 2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPB exp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783). Results Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95% CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95% CI]: 0.019 [0.007 to 0.031] m/s, p =.002, and 0.023 [0.012 to 0.034] m/sec, p <.0001, respectively) and higher SPPB exp scores (0.037 [0.011 to 0.063], p =.005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPB exp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p =.01). Conclusions An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes. ClinicalTrials.gov Identifier NCT00017953.

Original languageEnglish (US)
Pages (from-to)1552-1559
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume73
Issue number11
DOIs
StatePublished - Oct 8 2018

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Type 2 Diabetes Mellitus
Life Style
Education
Caloric Restriction
Hand Strength
Weight Loss
Lower Extremity
Body Mass Index
Exercise
Walking Speed

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes : The look AHEAD study. / Houston, Denise K.; Neiberg, Rebecca H.; Miller, Michael E.; Hill, James O.; Jakicic, John M.; Johnson, Karen; Gregg, Edward W.; Hubbard, Van S.; Pi-Sunyer, Xavier; Rejeski, W. Jack; Wing, Rena R.; Bantle, John P.; Beale, Elizabeth; Berkowitz, Robert I.; Cassidy-Begay, Maria; Clark, Jeanne M.; Coday, Mathilda; Delahanty, Linda M.; Dutton, Gareth; Egan, Caitlin; Foreyt, John P.; Greenway, Frank L.; Hazuda, Helen P.; Hergenroeder, Andrea; Horton, Edward S.; Jeffery, Robert W.; Kahn, Steven E.; Kure, Anne; Knowler, William C.; Lewis, Cora E.; Martin, Corby K.; Michaels, Sara; Montez, Maria G.; Nathan, David M.; Patricio, Jennifer; Peters, Anne; Pownall, Henry; Regensteiner, Judith; Steinburg, Helmut; Wadden, Thomas A.; White, Karen; Yanovski, Susan Z.; Zhang, Ping; Kritchevsky, Stephen B.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 73, No. 11, 08.10.2018, p. 1552-1559.

Research output: Contribution to journalArticle

Houston, DK, Neiberg, RH, Miller, ME, Hill, JO, Jakicic, JM, Johnson, K, Gregg, EW, Hubbard, VS, Pi-Sunyer, X, Rejeski, WJ, Wing, RR, Bantle, JP, Beale, E, Berkowitz, RI, Cassidy-Begay, M, Clark, JM, Coday, M, Delahanty, LM, Dutton, G, Egan, C, Foreyt, JP, Greenway, FL, Hazuda, HP, Hergenroeder, A, Horton, ES, Jeffery, RW, Kahn, SE, Kure, A, Knowler, WC, Lewis, CE, Martin, CK, Michaels, S, Montez, MG, Nathan, DM, Patricio, J, Peters, A, Pownall, H, Regensteiner, J, Steinburg, H, Wadden, TA, White, K, Yanovski, SZ, Zhang, P & Kritchevsky, SB 2018, 'Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes: The look AHEAD study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 73, no. 11, pp. 1552-1559. https://doi.org/10.1093/gerona/glx204
Houston, Denise K. ; Neiberg, Rebecca H. ; Miller, Michael E. ; Hill, James O. ; Jakicic, John M. ; Johnson, Karen ; Gregg, Edward W. ; Hubbard, Van S. ; Pi-Sunyer, Xavier ; Rejeski, W. Jack ; Wing, Rena R. ; Bantle, John P. ; Beale, Elizabeth ; Berkowitz, Robert I. ; Cassidy-Begay, Maria ; Clark, Jeanne M. ; Coday, Mathilda ; Delahanty, Linda M. ; Dutton, Gareth ; Egan, Caitlin ; Foreyt, John P. ; Greenway, Frank L. ; Hazuda, Helen P. ; Hergenroeder, Andrea ; Horton, Edward S. ; Jeffery, Robert W. ; Kahn, Steven E. ; Kure, Anne ; Knowler, William C. ; Lewis, Cora E. ; Martin, Corby K. ; Michaels, Sara ; Montez, Maria G. ; Nathan, David M. ; Patricio, Jennifer ; Peters, Anne ; Pownall, Henry ; Regensteiner, Judith ; Steinburg, Helmut ; Wadden, Thomas A. ; White, Karen ; Yanovski, Susan Z. ; Zhang, Ping ; Kritchevsky, Stephen B. / Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes : The look AHEAD study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2018 ; Vol. 73, No. 11. pp. 1552-1559.
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abstract = "Background Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods Overweight and obese (body mass index ≥ 25 kg/m 2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPB exp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783). Results Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95{\%} CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95{\%} CI]: 0.019 [0.007 to 0.031] m/s, p =.002, and 0.023 [0.012 to 0.034] m/sec, p <.0001, respectively) and higher SPPB exp scores (0.037 [0.011 to 0.063], p =.005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPB exp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p =.01). Conclusions An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes. ClinicalTrials.gov Identifier NCT00017953.",
author = "Houston, {Denise K.} and Neiberg, {Rebecca H.} and Miller, {Michael E.} and Hill, {James O.} and Jakicic, {John M.} and Karen Johnson and Gregg, {Edward W.} and Hubbard, {Van S.} and Xavier Pi-Sunyer and Rejeski, {W. Jack} and Wing, {Rena R.} and Bantle, {John P.} and Elizabeth Beale and Berkowitz, {Robert I.} and Maria Cassidy-Begay and Clark, {Jeanne M.} and Mathilda Coday and Delahanty, {Linda M.} and Gareth Dutton and Caitlin Egan and Foreyt, {John P.} and Greenway, {Frank L.} and Hazuda, {Helen P.} and Andrea Hergenroeder and Horton, {Edward S.} and Jeffery, {Robert W.} and Kahn, {Steven E.} and Anne Kure and Knowler, {William C.} and Lewis, {Cora E.} and Martin, {Corby K.} and Sara Michaels and Montez, {Maria G.} and Nathan, {David M.} and Jennifer Patricio and Anne Peters and Henry Pownall and Judith Regensteiner and Helmut Steinburg and Wadden, {Thomas A.} and Karen White and Yanovski, {Susan Z.} and Ping Zhang and Kritchevsky, {Stephen B.}",
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TY - JOUR

T1 - Physical function following a long-term lifestyle intervention among middle aged and older adults with type 2 diabetes

T2 - The look AHEAD study

AU - Houston, Denise K.

AU - Neiberg, Rebecca H.

AU - Miller, Michael E.

AU - Hill, James O.

AU - Jakicic, John M.

AU - Johnson, Karen

AU - Gregg, Edward W.

AU - Hubbard, Van S.

AU - Pi-Sunyer, Xavier

AU - Rejeski, W. Jack

AU - Wing, Rena R.

AU - Bantle, John P.

AU - Beale, Elizabeth

AU - Berkowitz, Robert I.

AU - Cassidy-Begay, Maria

AU - Clark, Jeanne M.

AU - Coday, Mathilda

AU - Delahanty, Linda M.

AU - Dutton, Gareth

AU - Egan, Caitlin

AU - Foreyt, John P.

AU - Greenway, Frank L.

AU - Hazuda, Helen P.

AU - Hergenroeder, Andrea

AU - Horton, Edward S.

AU - Jeffery, Robert W.

AU - Kahn, Steven E.

AU - Kure, Anne

AU - Knowler, William C.

AU - Lewis, Cora E.

AU - Martin, Corby K.

AU - Michaels, Sara

AU - Montez, Maria G.

AU - Nathan, David M.

AU - Patricio, Jennifer

AU - Peters, Anne

AU - Pownall, Henry

AU - Regensteiner, Judith

AU - Steinburg, Helmut

AU - Wadden, Thomas A.

AU - White, Karen

AU - Yanovski, Susan Z.

AU - Zhang, Ping

AU - Kritchevsky, Stephen B.

PY - 2018/10/8

Y1 - 2018/10/8

N2 - Background Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods Overweight and obese (body mass index ≥ 25 kg/m 2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPB exp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783). Results Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95% CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95% CI]: 0.019 [0.007 to 0.031] m/s, p =.002, and 0.023 [0.012 to 0.034] m/sec, p <.0001, respectively) and higher SPPB exp scores (0.037 [0.011 to 0.063], p =.005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPB exp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p =.01). Conclusions An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes. ClinicalTrials.gov Identifier NCT00017953.

AB - Background Lifestyle interventions have been shown to improve physical function over the short term; however, whether these benefits are sustainable is unknown. The long-term effects of an intensive lifestyle intervention (ILI) on physical function were assessed using a randomized post-test design in the Look AHEAD trial. Methods Overweight and obese (body mass index ≥ 25 kg/m 2) middle-aged and older adults (aged 45-76 years at enrollment) with type 2 diabetes enrolled in Look AHEAD, a trial evaluating an ILI designed to achieve weight loss through caloric restriction and increased physical activity compared to diabetes support and education (DSE), underwent standardized assessments of performance-based physical function including a 4- and 400-m walk, lower extremity physical performance (expanded Short Physical Performance Battery, SPPB exp), and grip strength approximately 11 years postrandomization and 1.5 years after the intervention was stopped (n = 3,783). Results Individuals randomized to ILI had lower odds of slow gait speed (<0.8 m/s) compared to those randomized to DSE (adjusted OR [95% CI]: 0.84 [0.71 to 0.99]). Individuals randomized to ILI also had faster gait speed over 4- and 400-m (adjusted mean difference [95% CI]: 0.019 [0.007 to 0.031] m/s, p =.002, and 0.023 [0.012 to 0.034] m/sec, p <.0001, respectively) and higher SPPB exp scores (0.037 [0.011 to 0.063], p =.005) compared to those randomized to DSE. The intervention effect was slightly larger for SPPB exp scores among older versus younger participants (0.081 [0.038 to 0.124] vs 0.013 [-0.021 to 0.047], p =.01). Conclusions An intensive lifestyle intervention has modest but significant long-term benefits on physical function in overweight and obese middle-aged and older adults with type 2 diabetes. ClinicalTrials.gov Identifier NCT00017953.

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JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

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