Physicochemical characteristics of drugs and response to repeat-dose activated charcoal

Jeffery W. Campbell, Peter Chyka

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Although the administration of repeated doses of activated charcoal has been advocated to increase the systemic clearance of many drugs, it is unknown whether a drug's physicochemical properties are associated with enhanced removal by repeat-dose activated charcoal. The English language literature was searched to identify clinical studies evaluating repeat-dose activated charcoal. Percent reduction in plasma elimination half-life during repeat-dose activated charcoal was calculated and correlated with the drugs' characteristics. A step-wise multiple regression analysis with the independent variables of the drugs' molecular weight, pKa, plasma protein-binding, intrinsic plasma elimination half-life, and volume of distribution falied to identify potential predictors (P = .1) of effectiveness of repeat-dose activated charcoal. This analysis suggested that charcoal therapy was more effective for drugs with a longer intrinsic half-life (r2 = .24, P = .04). A uniform framework that evaluates the physicochemical characteristics of drugs and their response to repeat-dose activated charcoal is needed to better define which patients would benefit from repeat-dose activated charcoal therapy.

Original languageEnglish (US)
Pages (from-to)208-210
Number of pages3
JournalAmerican Journal of Emergency Medicine
Volume10
Issue number3
DOIs
StatePublished - Jan 1 1992

Fingerprint

Charcoal
Pharmaceutical Preparations
Half-Life
Protein Binding
Blood Proteins
Language
Molecular Weight
Regression Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Emergency Medicine

Cite this

Physicochemical characteristics of drugs and response to repeat-dose activated charcoal. / Campbell, Jeffery W.; Chyka, Peter.

In: American Journal of Emergency Medicine, Vol. 10, No. 3, 01.01.1992, p. 208-210.

Research output: Contribution to journalArticle

@article{31409f7eaf894edbbae23f74072402ed,
title = "Physicochemical characteristics of drugs and response to repeat-dose activated charcoal",
abstract = "Although the administration of repeated doses of activated charcoal has been advocated to increase the systemic clearance of many drugs, it is unknown whether a drug's physicochemical properties are associated with enhanced removal by repeat-dose activated charcoal. The English language literature was searched to identify clinical studies evaluating repeat-dose activated charcoal. Percent reduction in plasma elimination half-life during repeat-dose activated charcoal was calculated and correlated with the drugs' characteristics. A step-wise multiple regression analysis with the independent variables of the drugs' molecular weight, pKa, plasma protein-binding, intrinsic plasma elimination half-life, and volume of distribution falied to identify potential predictors (P = .1) of effectiveness of repeat-dose activated charcoal. This analysis suggested that charcoal therapy was more effective for drugs with a longer intrinsic half-life (r2 = .24, P = .04). A uniform framework that evaluates the physicochemical characteristics of drugs and their response to repeat-dose activated charcoal is needed to better define which patients would benefit from repeat-dose activated charcoal therapy.",
author = "Campbell, {Jeffery W.} and Peter Chyka",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0735-6757(92)90210-O",
language = "English (US)",
volume = "10",
pages = "208--210",
journal = "American Journal of Emergency Medicine",
issn = "0735-6757",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Physicochemical characteristics of drugs and response to repeat-dose activated charcoal

AU - Campbell, Jeffery W.

AU - Chyka, Peter

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Although the administration of repeated doses of activated charcoal has been advocated to increase the systemic clearance of many drugs, it is unknown whether a drug's physicochemical properties are associated with enhanced removal by repeat-dose activated charcoal. The English language literature was searched to identify clinical studies evaluating repeat-dose activated charcoal. Percent reduction in plasma elimination half-life during repeat-dose activated charcoal was calculated and correlated with the drugs' characteristics. A step-wise multiple regression analysis with the independent variables of the drugs' molecular weight, pKa, plasma protein-binding, intrinsic plasma elimination half-life, and volume of distribution falied to identify potential predictors (P = .1) of effectiveness of repeat-dose activated charcoal. This analysis suggested that charcoal therapy was more effective for drugs with a longer intrinsic half-life (r2 = .24, P = .04). A uniform framework that evaluates the physicochemical characteristics of drugs and their response to repeat-dose activated charcoal is needed to better define which patients would benefit from repeat-dose activated charcoal therapy.

AB - Although the administration of repeated doses of activated charcoal has been advocated to increase the systemic clearance of many drugs, it is unknown whether a drug's physicochemical properties are associated with enhanced removal by repeat-dose activated charcoal. The English language literature was searched to identify clinical studies evaluating repeat-dose activated charcoal. Percent reduction in plasma elimination half-life during repeat-dose activated charcoal was calculated and correlated with the drugs' characteristics. A step-wise multiple regression analysis with the independent variables of the drugs' molecular weight, pKa, plasma protein-binding, intrinsic plasma elimination half-life, and volume of distribution falied to identify potential predictors (P = .1) of effectiveness of repeat-dose activated charcoal. This analysis suggested that charcoal therapy was more effective for drugs with a longer intrinsic half-life (r2 = .24, P = .04). A uniform framework that evaluates the physicochemical characteristics of drugs and their response to repeat-dose activated charcoal is needed to better define which patients would benefit from repeat-dose activated charcoal therapy.

UR - http://www.scopus.com/inward/record.url?scp=0026681296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026681296&partnerID=8YFLogxK

U2 - 10.1016/0735-6757(92)90210-O

DO - 10.1016/0735-6757(92)90210-O

M3 - Article

VL - 10

SP - 208

EP - 210

JO - American Journal of Emergency Medicine

JF - American Journal of Emergency Medicine

SN - 0735-6757

IS - 3

ER -