Physiological and hormonal factors that influence leptin production

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

The collective evidence from studies in rodents and humans indicate that leptin is a regulated hormone, whose actions straddle several behavioral, physiological, cellular, and molecular processes across diverse organ systems. This chapter discusses the physiological, hormonal, and metabolic factors involved in the synthesis and secretion of leptin and the regulation of circulating leptin levels in humans. Although leptin secretion was rarely measured directly in the existing reports, increases and decreases in circulating leptin levels are assumed to reflect similar changes in adipose tissue leptin production. The latter assumption is untenable in renal failure, where decreased leptin clearance becomes a factor in leptin abundance. The physiological factors that influence leptin secretion include gender, age, adiposity, physical exercise, feeding, and caloric restriction. Several hormones, including insulin, glucocorticoids, growth hormone, estradiol, testosterone, insulin-like growth factor-I, and somatostatin also modulate leptin secretion. In addition to alteration of circulating leptin levels, evidence of an effect on leptin synthesis (as indicated by adipose tissue leptin mRNA abundance) has been demonstrated for the effects of obesity and some of the hormones, such as insulin and glucocorticoids. Although mRNA abundance generally reflects synthesis, effects on mRNA stability have not been routinely investigated; thus, it is assumed that an increase in mRNA signifies increased synthesis. Where tissue evidence is lacking, it is assumed that the direction of alteration in circulating leptin levels reflects leptin production at the adipocyte level.

Original languageEnglish (US)
Title of host publicationLeptin
Subtitle of host publicationRegulation and Clinical Applications
PublisherSpringer International Publishing
Pages45-65
Number of pages21
ISBN (Electronic)9783319099156
ISBN (Print)9783319099149
DOIs
StatePublished - Jan 1 2015

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Leptin
Hormones
Messenger RNA
Glucocorticoids
Adipose Tissue
Insulin
Caloric Restriction
RNA Stability
Adiposity
Somatostatin
Insulin-Like Growth Factor I
Adipocytes
Growth Hormone
Renal Insufficiency
Testosterone
Estradiol
Rodentia
Obesity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Dagogo-Jack, S. (2015). Physiological and hormonal factors that influence leptin production. In Leptin: Regulation and Clinical Applications (pp. 45-65). Springer International Publishing. https://doi.org/10.1007/978-3-319-09915-6_5

Physiological and hormonal factors that influence leptin production. / Dagogo-Jack, Samuel.

Leptin: Regulation and Clinical Applications. Springer International Publishing, 2015. p. 45-65.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dagogo-Jack, S 2015, Physiological and hormonal factors that influence leptin production. in Leptin: Regulation and Clinical Applications. Springer International Publishing, pp. 45-65. https://doi.org/10.1007/978-3-319-09915-6_5
Dagogo-Jack S. Physiological and hormonal factors that influence leptin production. In Leptin: Regulation and Clinical Applications. Springer International Publishing. 2015. p. 45-65 https://doi.org/10.1007/978-3-319-09915-6_5
Dagogo-Jack, Samuel. / Physiological and hormonal factors that influence leptin production. Leptin: Regulation and Clinical Applications. Springer International Publishing, 2015. pp. 45-65
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