Physostigmine-induced reversal of EEG and behavioral effects of Δ9-tetrahydrocannabinol

Byron Jones, Paul F. Consroe, Faren Akins

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The effects of Δ9-THC) in combination with physostigmine (PHYSO) on the electroencephalogram (EEG) and behavior were measured in adult unrestrained rabbits. The increase in mean cortical electrogenesis (voltage output) of the EEG induced by Δ9-THC was clearly reversed by PHYSO. Hippocampal theta rhythm disrupted by Δ9-THC was restored by PHYSO. Physostigmine also antagonized Δ9-THC-induced alteration of postural and activity behaviors. Except for very brief periods of retching, no behavioral indications of toxicity were observed.

Original languageEnglish (US)
Pages (from-to)204-206
Number of pages3
JournalBulletin of the Psychonomic Society
Volume6
Issue number2
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

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Physostigmine
Dronabinol
Electroencephalography
Toxicity
Electric potential

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Physostigmine-induced reversal of EEG and behavioral effects of Δ9-tetrahydrocannabinol. / Jones, Byron; Consroe, Paul F.; Akins, Faren.

In: Bulletin of the Psychonomic Society, Vol. 6, No. 2, 01.01.1975, p. 204-206.

Research output: Contribution to journalArticle

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