Placebo-controlled, 6-week clinical trial on the safety and efficacy of a low-gel, 14% hydrogen-peroxide whitening strip.

Franklin Garcia-Godoy, Patricia Villalta, Matthew L. Barker, Robert W. Gerlach

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Clinical research was conducted to evaluate the extended-use safety and efficacy of Crest Whitestrips Supreme, a low-gel (100 mg on maxillary strip), 14% hydrogen-peroxide professional tooth-whitening system. The parallel-group study was randomized, double-blind, and placebo-controlled, and involved 39 healthy adults. During the treatment phase, subjects used the investigational products twice daily (for 30 minutes each) for 6 weeks (42 days). Safety and efficacy measurements were obtained at baseline and at the completion of each 3-week treatment period. Results showed that twice-daily use of Crest Whitestrips Supreme for 3 weeks resulted in a highly significant (P < .0001) improvement in tooth color, with a mean yellowness reduction (delta b*) of -3.3 and a mean brightness improvement (delta L*) of 2.4 relative to placebo. Color improvement continued with extended strip use over 6 weeks for all parameters (P < .0005). Relative to placebo at 6 weeks, color improvement was highly significant (P < .0001), with a mean delta b* of -4.1 and a mean delta L* of 3.2. Mild and transient tooth sensitivity and oral irritation were the most common adverse events. There was no evidence of any meaningful increase in adverse events with extended treatment through 6 weeks. Twice-daily use of Crest Whitestrips Supreme resulted in a highly significant improvement in tooth color after 3 weeks, with color improvement continuing over 6 weeks.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalCompendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
Volume25
Issue number8 Suppl 2
StatePublished - Jan 1 2004
Externally publishedYes

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Hydrogen Peroxide
Color
Gels
Placebos
Clinical Trials
Safety
Tooth
Dentin Sensitivity
Tooth Bleaching
Therapeutics
Research
Crest whitestrips

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Placebo-controlled, 6-week clinical trial on the safety and efficacy of a low-gel, 14% hydrogen-peroxide whitening strip. / Garcia-Godoy, Franklin; Villalta, Patricia; Barker, Matthew L.; Gerlach, Robert W.

In: Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), Vol. 25, No. 8 Suppl 2, 01.01.2004, p. 21-26.

Research output: Contribution to journalArticle

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