Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients

A pilot study

William Grady on behalf of the ColoCare Consortium

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Vitamin D and folate are associated with decreased colorectal cancer risk and their association with colorectal cancer prognosis is under investigation. We assessed the levels of plasma 25-hydroxyvitamin D3 (25(OH)D3), folate and vitamin B12 in an international pilot study in order to determine variability of these biomarkers based on geographical location. Plasma 25(OH)D3, folate and vitamin B12 concentrations were measured in 149 invasive, newly diagnosed colorectal cancer cases from Heidelberg (Germany), Seattle (WA, USA), and Tampa (FL, USA) and in ninety-one age- and sex-matched controls. Their associations with potential predictors were assessed using multivariate linear regression analyses. Plasma 25(OH)D3, folate and vitamin B12 concentrations differed by location. Other predictors were season for 25(OH)D3 and tumour stage (vitamin B12). Season-corrected average 25(OH)D3 concentrations were higher in Heidelberg (31·7 ng/ml; range 11·0-83·0 ng/ml) than in Seattle (23·3 ng/ml; range 4·0-80·0 ng/ml) and Tampa (21·1 ng/ml; range 4·6-51·6 ng/ml). In Heidelberg, a strong seasonal variation was observed. Folate (11·1 ng/ml) and vitamin B12 (395 pg/ml) concentrations in Heidelberg were lower than those in Seattle (25·3 ng/ml and 740 pg/ml, respectively) and Tampa (23·8 ng/ml and 522 pg/ml, respectively). Differences in plasma 25 (OH)D3 and folate concentrations between Heidelberg and the US sites were observed, probably reflecting variation in outdoor activities and sun-avoidance behaviour during summer as well as in folic acid fortification and supplement use. Intra-site differences at each study location were greater than between-location variability, suggesting that individual health behaviours play a significant role. Nevertheless, the intra-site differences we observed may be due to chance because of the limited sample size. Our pilot study illustrates the value of an international cohort in studying colorectal cancer prognosis to discern geographical differences in a broad range of exposures.

Original languageEnglish (US)
Article numbere9
Pages (from-to)1-6
Number of pages6
JournalJournal of Nutritional Science
Volume2
DOIs
StatePublished - Jan 1 2013

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25-hydroxycholecalciferol
Calcifediol
vitamin B12
Vitamin B 12
colorectal neoplasms
Folic Acid
folic acid
Colorectal Neoplasms
biomarkers
Biomarkers
prognosis
Avoidance Learning
avoidance behavior
Health Behavior
Geographical Locations
Solar System
vitamin D
Vitamin D
Sample Size
Germany

All Science Journal Classification (ASJC) codes

  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma 25-hydroxyvitamin D3, folate and vitamin B12 biomarkers among international colorectal cancer patients : A pilot study. / William Grady on behalf of the ColoCare Consortium.

In: Journal of Nutritional Science, Vol. 2, e9, 01.01.2013, p. 1-6.

Research output: Contribution to journalArticle

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