Plasma exchange and prednisone in acute inflammatory polyradiculoneuropathy

A controlled randomized trial

J. R. Mendell, J. T. Kissel, M. S. Kennedy, Z. Sahenk, H. T. Grinvalsky, G. L. Pittman, R. S. Kyler, R. I. Roelofs, J. N. Whitaker, Tulio Bertorini

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A controlled‐randomized trial of plasma exchange combined with prednisone was compared to supportive care alone in patients with acute inflammatory polyradiculoneuropathy (AIP). The design of this study differs from other reported trials of plasma exchange in AIP because prednisone was used in the treatment group to prevent the possibility of antibody rebound. Furthermore, in this study, detailed muscle strength testing formed the principal basis for assessment of therapeutic efficacy while in the British, North American, and French studies, a functional assessment scale was used. Analysis of our data revealed no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95% chance) to detect a change of two British Medical Research Council grades of strength between the groups. The difference in our results versus others (North American and French studies) probably reflects the adverse effects of prednisone on recovery in AIP. An additional consideration is that plasma exchange may have an overall modest effect on the course of AIP, less appreciated when individual muscles are tested compared to assessment by large functional categories.

Original languageEnglish (US)
Pages (from-to)332-342
Number of pages11
JournalJournal of Clinical Apheresis
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Plasma Exchange
Guillain-Barre Syndrome
Prednisone
Randomized Controlled Trials
Muscle Strength
Sample Size
Biomedical Research
Muscles
Control Groups
Antibodies
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Plasma exchange and prednisone in acute inflammatory polyradiculoneuropathy : A controlled randomized trial. / Mendell, J. R.; Kissel, J. T.; Kennedy, M. S.; Sahenk, Z.; Grinvalsky, H. T.; Pittman, G. L.; Kyler, R. S.; Roelofs, R. I.; Whitaker, J. N.; Bertorini, Tulio.

In: Journal of Clinical Apheresis, Vol. 2, No. 4, 01.01.1985, p. 332-342.

Research output: Contribution to journalArticle

Mendell, JR, Kissel, JT, Kennedy, MS, Sahenk, Z, Grinvalsky, HT, Pittman, GL, Kyler, RS, Roelofs, RI, Whitaker, JN & Bertorini, T 1985, 'Plasma exchange and prednisone in acute inflammatory polyradiculoneuropathy: A controlled randomized trial', Journal of Clinical Apheresis, vol. 2, no. 4, pp. 332-342. https://doi.org/10.1002/jca.2920020419
Mendell, J. R. ; Kissel, J. T. ; Kennedy, M. S. ; Sahenk, Z. ; Grinvalsky, H. T. ; Pittman, G. L. ; Kyler, R. S. ; Roelofs, R. I. ; Whitaker, J. N. ; Bertorini, Tulio. / Plasma exchange and prednisone in acute inflammatory polyradiculoneuropathy : A controlled randomized trial. In: Journal of Clinical Apheresis. 1985 ; Vol. 2, No. 4. pp. 332-342.
@article{e7b64eaea87b4488b04c5b44d2cff181,
title = "Plasma exchange and prednisone in acute inflammatory polyradiculoneuropathy: A controlled randomized trial",
abstract = "A controlled‐randomized trial of plasma exchange combined with prednisone was compared to supportive care alone in patients with acute inflammatory polyradiculoneuropathy (AIP). The design of this study differs from other reported trials of plasma exchange in AIP because prednisone was used in the treatment group to prevent the possibility of antibody rebound. Furthermore, in this study, detailed muscle strength testing formed the principal basis for assessment of therapeutic efficacy while in the British, North American, and French studies, a functional assessment scale was used. Analysis of our data revealed no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95{\%} chance) to detect a change of two British Medical Research Council grades of strength between the groups. The difference in our results versus others (North American and French studies) probably reflects the adverse effects of prednisone on recovery in AIP. An additional consideration is that plasma exchange may have an overall modest effect on the course of AIP, less appreciated when individual muscles are tested compared to assessment by large functional categories.",
author = "Mendell, {J. R.} and Kissel, {J. T.} and Kennedy, {M. S.} and Z. Sahenk and Grinvalsky, {H. T.} and Pittman, {G. L.} and Kyler, {R. S.} and Roelofs, {R. I.} and Whitaker, {J. N.} and Tulio Bertorini",
year = "1985",
month = "1",
day = "1",
doi = "10.1002/jca.2920020419",
language = "English (US)",
volume = "2",
pages = "332--342",
journal = "Journal of Clinical Apheresis",
issn = "0733-2459",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Plasma exchange and prednisone in acute inflammatory polyradiculoneuropathy

T2 - A controlled randomized trial

AU - Mendell, J. R.

AU - Kissel, J. T.

AU - Kennedy, M. S.

AU - Sahenk, Z.

AU - Grinvalsky, H. T.

AU - Pittman, G. L.

AU - Kyler, R. S.

AU - Roelofs, R. I.

AU - Whitaker, J. N.

AU - Bertorini, Tulio

PY - 1985/1/1

Y1 - 1985/1/1

N2 - A controlled‐randomized trial of plasma exchange combined with prednisone was compared to supportive care alone in patients with acute inflammatory polyradiculoneuropathy (AIP). The design of this study differs from other reported trials of plasma exchange in AIP because prednisone was used in the treatment group to prevent the possibility of antibody rebound. Furthermore, in this study, detailed muscle strength testing formed the principal basis for assessment of therapeutic efficacy while in the British, North American, and French studies, a functional assessment scale was used. Analysis of our data revealed no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95% chance) to detect a change of two British Medical Research Council grades of strength between the groups. The difference in our results versus others (North American and French studies) probably reflects the adverse effects of prednisone on recovery in AIP. An additional consideration is that plasma exchange may have an overall modest effect on the course of AIP, less appreciated when individual muscles are tested compared to assessment by large functional categories.

AB - A controlled‐randomized trial of plasma exchange combined with prednisone was compared to supportive care alone in patients with acute inflammatory polyradiculoneuropathy (AIP). The design of this study differs from other reported trials of plasma exchange in AIP because prednisone was used in the treatment group to prevent the possibility of antibody rebound. Furthermore, in this study, detailed muscle strength testing formed the principal basis for assessment of therapeutic efficacy while in the British, North American, and French studies, a functional assessment scale was used. Analysis of our data revealed no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95% chance) to detect a change of two British Medical Research Council grades of strength between the groups. The difference in our results versus others (North American and French studies) probably reflects the adverse effects of prednisone on recovery in AIP. An additional consideration is that plasma exchange may have an overall modest effect on the course of AIP, less appreciated when individual muscles are tested compared to assessment by large functional categories.

UR - http://www.scopus.com/inward/record.url?scp=0022390696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022390696&partnerID=8YFLogxK

U2 - 10.1002/jca.2920020419

DO - 10.1002/jca.2920020419

M3 - Article

VL - 2

SP - 332

EP - 342

JO - Journal of Clinical Apheresis

JF - Journal of Clinical Apheresis

SN - 0733-2459

IS - 4

ER -