Plasma exchange and prednisone in Guillain-Barré syndrome

A controlled randomized trial

J. R. Mendell, J. T. Kissel, M. S. Kennedy, Z. Sahenk, H. T. Grinvalsky, G. L. Pittman, R. S. Kyler, R. I. Roelofs, J. N. Whitaker, Tulio Bertorini

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

A controlled randomized trial of plasma exchange combined with prednisone was compared with supportive care alone in patients with Guillain-Barré syndrome (GBS). There was no significant improvement in the treated group over the controls. The sample size, albeit small (12 treated and 13 controls), had the power (95% chance) to detect a change of 2 British Medical Research Council grades of strength between the groups. The difference in our results and others that indicated a beneficial effect of plasma exchange may reflect an adverse effect of prednisone on recovery in GBS. Failure to find a benefit of plasma exchange in our patients also raises the possibility that GBS may be a heterogeneous disorder with humoral factors playing a role in some but not all patients.

Original languageEnglish (US)
Pages (from-to)1551-1555
Number of pages5
JournalNeurology
Volume35
Issue number11
StatePublished - Jan 1 1985
Externally publishedYes

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Plasma Exchange
Prednisone
Randomized Controlled Trials
Sample Size
Biomedical Research
Control Groups

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Mendell, J. R., Kissel, J. T., Kennedy, M. S., Sahenk, Z., Grinvalsky, H. T., Pittman, G. L., ... Bertorini, T. (1985). Plasma exchange and prednisone in Guillain-Barré syndrome: A controlled randomized trial. Neurology, 35(11), 1551-1555.

Plasma exchange and prednisone in Guillain-Barré syndrome : A controlled randomized trial. / Mendell, J. R.; Kissel, J. T.; Kennedy, M. S.; Sahenk, Z.; Grinvalsky, H. T.; Pittman, G. L.; Kyler, R. S.; Roelofs, R. I.; Whitaker, J. N.; Bertorini, Tulio.

In: Neurology, Vol. 35, No. 11, 01.01.1985, p. 1551-1555.

Research output: Contribution to journalArticle

Mendell, JR, Kissel, JT, Kennedy, MS, Sahenk, Z, Grinvalsky, HT, Pittman, GL, Kyler, RS, Roelofs, RI, Whitaker, JN & Bertorini, T 1985, 'Plasma exchange and prednisone in Guillain-Barré syndrome: A controlled randomized trial', Neurology, vol. 35, no. 11, pp. 1551-1555.
Mendell JR, Kissel JT, Kennedy MS, Sahenk Z, Grinvalsky HT, Pittman GL et al. Plasma exchange and prednisone in Guillain-Barré syndrome: A controlled randomized trial. Neurology. 1985 Jan 1;35(11):1551-1555.
Mendell, J. R. ; Kissel, J. T. ; Kennedy, M. S. ; Sahenk, Z. ; Grinvalsky, H. T. ; Pittman, G. L. ; Kyler, R. S. ; Roelofs, R. I. ; Whitaker, J. N. ; Bertorini, Tulio. / Plasma exchange and prednisone in Guillain-Barré syndrome : A controlled randomized trial. In: Neurology. 1985 ; Vol. 35, No. 11. pp. 1551-1555.
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