Plasma Immunoreactive β-Endorphin Levels in Depression

Effect of Electroconvulsive Therapy

George S. Alexopoulos, Charles E. Inturrisi, Robert Lipman, Richard Frances, Jane Haycox, John Dougherty, Jean Rossier

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Immunoreactive (ir) plasma β-endorphin level was assayed in ten symptomatic patients with a unipolar major depressive disorder and in 16 psychiatrically normal controls matched for age and sex. Plasma ir-β-endorphin level in depressed patients was similar to that in controls. All depressed patients had a transient, approximately threefold increase in ir-β-endorphin after each use of electroconvulsive therapy (ECT). The increase of plasma ir-β-endorphin level after ECT parallels the transient elevation of adrenocorticotropic hormone-level reported by others and probably reflects a hypothalamic response to ECT.

Original languageEnglish (US)
Pages (from-to)181-183
Number of pages3
JournalArchives of General Psychiatry
Volume40
Issue number2
DOIs
StatePublished - Jan 1 1983

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Endorphins
Electroconvulsive Therapy
Depression
Major Depressive Disorder
Adrenocorticotropic Hormone
Therapy
Plasma

All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Plasma Immunoreactive β-Endorphin Levels in Depression : Effect of Electroconvulsive Therapy. / Alexopoulos, George S.; Inturrisi, Charles E.; Lipman, Robert; Frances, Richard; Haycox, Jane; Dougherty, John; Rossier, Jean.

In: Archives of General Psychiatry, Vol. 40, No. 2, 01.01.1983, p. 181-183.

Research output: Contribution to journalArticle

Alexopoulos, George S. ; Inturrisi, Charles E. ; Lipman, Robert ; Frances, Richard ; Haycox, Jane ; Dougherty, John ; Rossier, Jean. / Plasma Immunoreactive β-Endorphin Levels in Depression : Effect of Electroconvulsive Therapy. In: Archives of General Psychiatry. 1983 ; Vol. 40, No. 2. pp. 181-183.
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