Plasma lipid levels predict dysglycemia in a biracial cohort of nondiabetic subjects

Potential mechanisms

Ibiye Owei, Nkiru Umekwe, Jim Wan, Samuel Dagogo-Jack

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Dyslipidemia and dysglycemia are etiologically associated, but the direction, chronology, and mechanisms of the association are not fully understood. We, therefore, analyzed data from 335 healthy adults (184 black, 151 white) enrolled in the Pathobiology of Prediabetes in A Biracial Cohort study. Subjects underwent oral glucose tolerance test (OGTT) and were enrolled if they had normal fasting and 2-h plasma glucose levels. Assessments during year 1 included anthropometry, fasting lipid profile, insulin sensitivity, and insulin secretion. Thereafter, OGTT was assessed annually for 5.5 years. The primary outcome was occurrence of prediabetes (impaired fasting glucose or impaired glucose tolerance) or diabetes. During a mean follow-up of 2.62 years, 110 participants (32.8%) developed prediabetes (N = 100) or diabetes (N = 10). In multivariate logistic regression models, higher baseline low-density lipoprotein (LDL) cholesterol and triglyceride levels and lower HDL cholesterol levels significantly increased the risk of incident prediabetes. The combined relative risk (95% confidence interval [CI]) of prediabetes for participants with lower baseline HDL cholesterol (10th vs. 90th percentile), higher LDL cholesterol (90th vs. 10th percentile) and high triglycerides levels (90th vs. 10th percentile) was 4.12 (95% CI 1.61–10.56), P = 0.0032. At baseline, lipid values showed significant associations with measures of adiposity, glycemia, insulin sensitivity, and secretion. In both ethnic groups, waist circumference correlated positively with triglycerides and inversely with HDL cholesterol levels (P = 0.0004–<0.0001); fasting plasma glucose correlated positively with triglycerides and LDL cholesterol levels and inversely with HDL cholesterol levels (P = 0.006–<0.0001); insulin sensitivity correlated positively with HDL cholesterol and inversely with triglyceride levels (P < 0.0001), and insulin secretion correlated positively with triglycerides (P = 0.01) and inversely with HDL cholesterol (P < 0.0001). We conclude that a baseline lipidemic signature identifies normoglycemic individuals at high risk for future glycemic progression, via congruent associations with adiposity and glucoregulatory mechanisms. These findings suggest that early lifestyle intervention could ameliorate progressive dyslipidemia and dysglycemia.

Original languageEnglish (US)
Pages (from-to)1961-1967
Number of pages7
JournalExperimental Biology and Medicine
Volume241
Issue number17
DOIs
StatePublished - Nov 1 2016

Fingerprint

Prediabetic State
HDL Cholesterol
Lipids
Plasmas
Glucose
Insulin
Triglycerides
Fasting
LDL Cholesterol
Insulin Resistance
Medical problems
Adiposity
Glucose Tolerance Test
Dyslipidemias
Anthropometry
Logistic Models
Confidence Intervals
Chronology
Glucose Intolerance
Waist Circumference

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Plasma lipid levels predict dysglycemia in a biracial cohort of nondiabetic subjects : Potential mechanisms. / Owei, Ibiye; Umekwe, Nkiru; Wan, Jim; Dagogo-Jack, Samuel.

In: Experimental Biology and Medicine, Vol. 241, No. 17, 01.11.2016, p. 1961-1967.

Research output: Contribution to journalArticle

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