Plasma proteins interaction with curcumin nanoparticles

Implications in cancer therapeutics

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Curcumin, a natural bioactive polyphenol, has been widely investigated as a conventional medicine for centuries. Over the past two decades, major pre-clinical and clinical trials have demonstrated its safe therapeutic profile but clinical translation has been hampered due to rapid degradation, poor water solubility, bioavailability and pharmaco-kinetics. To overcome such translational issues, many laboratories have focused on developing curcumin nanoformulations for cancer therapeutics. In this review, we discuss the evolution of cur-cumin nanomedicine in cancer therapeutics, the possible interactions between the surface of curcumin nanoparticles and plasma proteins, the role of nanoparticle-protein complex architecture parameters, and the rational design of clinically useful curcumin nanoformulations. Considering all the biologically relevant phenomena, curcumin nanoformulations can be developed as a new neutraceutical or pharmaceutical agent.

Original languageEnglish (US)
Pages (from-to)504-515
Number of pages12
JournalCurrent Drug Metabolism
Volume14
Issue number4
DOIs
StatePublished - May 1 2013

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Curcumin
Nanoparticles
Blood Proteins
Neoplasms
Cuminum
Nanomedicine
Medical nanotechnology
Therapeutics
Pharmacokinetics
Polyphenols
Dietary Supplements
Solubility
Biological Availability
Medicine
Clinical Trials
Degradation
Water
Pharmaceutical Preparations
Proteins

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Biochemistry

Cite this

Plasma proteins interaction with curcumin nanoparticles : Implications in cancer therapeutics. / Yallapu, Murali; Ebeling, Mara C.; Jaggi, Meena; Chauhan, Subhash.

In: Current Drug Metabolism, Vol. 14, No. 4, 01.05.2013, p. 504-515.

Research output: Contribution to journalArticle

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