Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy

G. Bhanuprakash Reddy, M. Sivaprasad, T. Shalini, Satyanarayana Alleboina, M. Seshacharyulu, N. Balakrishna, K. Viswanath, Manisha Sahay

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Diabetic retinopathy (DR) is a common cause of blindness. Although an association between hypovitaminosis D and type 1 diabetes is known, the association between vitamin D (VD) and type 2 diabetes (T2D) and its complications such as DR has been unclear. The aim of this study was to investigate the status of VD in T2D patients with and without DR. Methods: A cross-sectional case-control study was conducted with 99 normal control (CN) participants and 164 patients with T2D, of which 82 had retinopathy (DR) and 82 did not (DNR). After a complete ophthalmic examination, inclusive of fundus fluorescein angiography, the clinical profile and the plasma levels of VD and calcium were analyzed. Results: Although the mean plasma VD levels were significantly lower in the DNR and DR groups compared with the CN group, no significant differences were observed between the groups with diabetes. Although the mean levels of VD in all three groups were below the normal range, the prevalence of VD deficiency (VDD) was higher in the DNR and DR groups (66% and 63%) than in the CN group (45%), suggesting that the prevalence of VDD was higher in individuals with diabetes, regardless of the presence or absence of retinopathy. However, there were no group differences in the plasma levels of calcium. Additionally, VDD did not seem to be related to patient's age or body mass index, but was related to the duration of diabetes. Conclusion: Results from this study suggest a possible association between VDD and T2D, but not specifically with DR. Further investigations are warranted.

Original languageEnglish (US)
Pages (from-to)959-963
Number of pages5
JournalNutrition
Volume31
Issue number7-8
DOIs
StatePublished - Jan 1 2015

Fingerprint

Diabetic Retinopathy
Vitamin D
Type 2 Diabetes Mellitus
Ergocalciferols
Calcium
Control Groups
Vitamin D Deficiency
Fluorescein Angiography
Diabetes Complications
Blindness
Type 1 Diabetes Mellitus
Case-Control Studies
Reference Values
Body Mass Index

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Reddy, G. B., Sivaprasad, M., Shalini, T., Alleboina, S., Seshacharyulu, M., Balakrishna, N., ... Sahay, M. (2015). Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy. Nutrition, 31(7-8), 959-963. https://doi.org/10.1016/j.nut.2015.01.012

Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy. / Reddy, G. Bhanuprakash; Sivaprasad, M.; Shalini, T.; Alleboina, Satyanarayana; Seshacharyulu, M.; Balakrishna, N.; Viswanath, K.; Sahay, Manisha.

In: Nutrition, Vol. 31, No. 7-8, 01.01.2015, p. 959-963.

Research output: Contribution to journalArticle

Reddy, GB, Sivaprasad, M, Shalini, T, Alleboina, S, Seshacharyulu, M, Balakrishna, N, Viswanath, K & Sahay, M 2015, 'Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy', Nutrition, vol. 31, no. 7-8, pp. 959-963. https://doi.org/10.1016/j.nut.2015.01.012
Reddy GB, Sivaprasad M, Shalini T, Alleboina S, Seshacharyulu M, Balakrishna N et al. Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy. Nutrition. 2015 Jan 1;31(7-8):959-963. https://doi.org/10.1016/j.nut.2015.01.012
Reddy, G. Bhanuprakash ; Sivaprasad, M. ; Shalini, T. ; Alleboina, Satyanarayana ; Seshacharyulu, M. ; Balakrishna, N. ; Viswanath, K. ; Sahay, Manisha. / Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy. In: Nutrition. 2015 ; Vol. 31, No. 7-8. pp. 959-963.
@article{9ffa8578293f4e528db4a209dfef5d7f,
title = "Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy",
abstract = "Objective: Diabetic retinopathy (DR) is a common cause of blindness. Although an association between hypovitaminosis D and type 1 diabetes is known, the association between vitamin D (VD) and type 2 diabetes (T2D) and its complications such as DR has been unclear. The aim of this study was to investigate the status of VD in T2D patients with and without DR. Methods: A cross-sectional case-control study was conducted with 99 normal control (CN) participants and 164 patients with T2D, of which 82 had retinopathy (DR) and 82 did not (DNR). After a complete ophthalmic examination, inclusive of fundus fluorescein angiography, the clinical profile and the plasma levels of VD and calcium were analyzed. Results: Although the mean plasma VD levels were significantly lower in the DNR and DR groups compared with the CN group, no significant differences were observed between the groups with diabetes. Although the mean levels of VD in all three groups were below the normal range, the prevalence of VD deficiency (VDD) was higher in the DNR and DR groups (66{\%} and 63{\%}) than in the CN group (45{\%}), suggesting that the prevalence of VDD was higher in individuals with diabetes, regardless of the presence or absence of retinopathy. However, there were no group differences in the plasma levels of calcium. Additionally, VDD did not seem to be related to patient's age or body mass index, but was related to the duration of diabetes. Conclusion: Results from this study suggest a possible association between VDD and T2D, but not specifically with DR. Further investigations are warranted.",
author = "Reddy, {G. Bhanuprakash} and M. Sivaprasad and T. Shalini and Satyanarayana Alleboina and M. Seshacharyulu and N. Balakrishna and K. Viswanath and Manisha Sahay",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.nut.2015.01.012",
language = "English (US)",
volume = "31",
pages = "959--963",
journal = "Nutrition",
issn = "0899-9007",
publisher = "Elsevier Inc.",
number = "7-8",

}

TY - JOUR

T1 - Plasma vitamin D status in patients with type 2 diabetes with and without retinopathy

AU - Reddy, G. Bhanuprakash

AU - Sivaprasad, M.

AU - Shalini, T.

AU - Alleboina, Satyanarayana

AU - Seshacharyulu, M.

AU - Balakrishna, N.

AU - Viswanath, K.

AU - Sahay, Manisha

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objective: Diabetic retinopathy (DR) is a common cause of blindness. Although an association between hypovitaminosis D and type 1 diabetes is known, the association between vitamin D (VD) and type 2 diabetes (T2D) and its complications such as DR has been unclear. The aim of this study was to investigate the status of VD in T2D patients with and without DR. Methods: A cross-sectional case-control study was conducted with 99 normal control (CN) participants and 164 patients with T2D, of which 82 had retinopathy (DR) and 82 did not (DNR). After a complete ophthalmic examination, inclusive of fundus fluorescein angiography, the clinical profile and the plasma levels of VD and calcium were analyzed. Results: Although the mean plasma VD levels were significantly lower in the DNR and DR groups compared with the CN group, no significant differences were observed between the groups with diabetes. Although the mean levels of VD in all three groups were below the normal range, the prevalence of VD deficiency (VDD) was higher in the DNR and DR groups (66% and 63%) than in the CN group (45%), suggesting that the prevalence of VDD was higher in individuals with diabetes, regardless of the presence or absence of retinopathy. However, there were no group differences in the plasma levels of calcium. Additionally, VDD did not seem to be related to patient's age or body mass index, but was related to the duration of diabetes. Conclusion: Results from this study suggest a possible association between VDD and T2D, but not specifically with DR. Further investigations are warranted.

AB - Objective: Diabetic retinopathy (DR) is a common cause of blindness. Although an association between hypovitaminosis D and type 1 diabetes is known, the association between vitamin D (VD) and type 2 diabetes (T2D) and its complications such as DR has been unclear. The aim of this study was to investigate the status of VD in T2D patients with and without DR. Methods: A cross-sectional case-control study was conducted with 99 normal control (CN) participants and 164 patients with T2D, of which 82 had retinopathy (DR) and 82 did not (DNR). After a complete ophthalmic examination, inclusive of fundus fluorescein angiography, the clinical profile and the plasma levels of VD and calcium were analyzed. Results: Although the mean plasma VD levels were significantly lower in the DNR and DR groups compared with the CN group, no significant differences were observed between the groups with diabetes. Although the mean levels of VD in all three groups were below the normal range, the prevalence of VD deficiency (VDD) was higher in the DNR and DR groups (66% and 63%) than in the CN group (45%), suggesting that the prevalence of VDD was higher in individuals with diabetes, regardless of the presence or absence of retinopathy. However, there were no group differences in the plasma levels of calcium. Additionally, VDD did not seem to be related to patient's age or body mass index, but was related to the duration of diabetes. Conclusion: Results from this study suggest a possible association between VDD and T2D, but not specifically with DR. Further investigations are warranted.

UR - http://www.scopus.com/inward/record.url?scp=84945937806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945937806&partnerID=8YFLogxK

U2 - 10.1016/j.nut.2015.01.012

DO - 10.1016/j.nut.2015.01.012

M3 - Article

C2 - 26059368

AN - SCOPUS:84945937806

VL - 31

SP - 959

EP - 963

JO - Nutrition

JF - Nutrition

SN - 0899-9007

IS - 7-8

ER -