Plasmablastic lymphoma in a previously undiagnosed aids patient

A case report

Francisco O. Vieira, Omar El Gandour, Francis K. Buadi, Glenn B. Williams, Courtney B. Shires, Nadeem Zafar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background Plasmablastic lymphoma (PBL) is an unusual non-Hodgkin lymphoma (NHL) most commonly found in the head and neck region. The majority of cases are seen in adult HIV-positive patients, although PBL has been reported in HIV-negative patients. The diagnosis of PBL serves as an AIDS-defining illness. Methods We report a case of PBL localized to the oral cavity in a previously undiagnosed AIDS patient. The lesion manifested as solitary, ulcerated, and markedly tender. PBL was confirmed by immunohistochemical profile and subsequent tests confirmed AIDS diagnosis. The patient was prescribed highly active antiretroviral therapy (HAART) and concomitant local low dose radiation therapy prior to initiation of chemotherapy. Results Complete local clinical response was observed after 4 weeks of treatment with HAART and radiation therapy. The response sustained in this patient in the subsequent 11 months following diagnosis. Conclusions The diagnosis of PBL has a unique immunophenotypic profile and should raise suspicion for AIDS in these patients. HAART added to treatment has shown improved survival.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalHead and Neck Pathology
Volume2
Issue number2
DOIs
StatePublished - Dec 1 2008

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Highly Active Antiretroviral Therapy
Acquired Immunodeficiency Syndrome
Radiotherapy
HIV
Non-Hodgkin's Lymphoma
Mouth
Plasmablastic Lymphoma
Neck
Head
Drug Therapy
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oncology
  • Otorhinolaryngology

Cite this

Vieira, F. O., El Gandour, O., Buadi, F. K., Williams, G. B., Shires, C. B., & Zafar, N. (2008). Plasmablastic lymphoma in a previously undiagnosed aids patient: A case report. Head and Neck Pathology, 2(2), 92-96. https://doi.org/10.1007/s12105-008-0058-1

Plasmablastic lymphoma in a previously undiagnosed aids patient : A case report. / Vieira, Francisco O.; El Gandour, Omar; Buadi, Francis K.; Williams, Glenn B.; Shires, Courtney B.; Zafar, Nadeem.

In: Head and Neck Pathology, Vol. 2, No. 2, 01.12.2008, p. 92-96.

Research output: Contribution to journalArticle

Vieira, FO, El Gandour, O, Buadi, FK, Williams, GB, Shires, CB & Zafar, N 2008, 'Plasmablastic lymphoma in a previously undiagnosed aids patient: A case report', Head and Neck Pathology, vol. 2, no. 2, pp. 92-96. https://doi.org/10.1007/s12105-008-0058-1
Vieira FO, El Gandour O, Buadi FK, Williams GB, Shires CB, Zafar N. Plasmablastic lymphoma in a previously undiagnosed aids patient: A case report. Head and Neck Pathology. 2008 Dec 1;2(2):92-96. https://doi.org/10.1007/s12105-008-0058-1
Vieira, Francisco O. ; El Gandour, Omar ; Buadi, Francis K. ; Williams, Glenn B. ; Shires, Courtney B. ; Zafar, Nadeem. / Plasmablastic lymphoma in a previously undiagnosed aids patient : A case report. In: Head and Neck Pathology. 2008 ; Vol. 2, No. 2. pp. 92-96.
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