PLATELET ACTIVATION IN ACUTE CEREBRAL ISCHÆMIA. Serial Measurements of Platelet Function in Cerebrovascular Disease

John Dougherty, D. E. Levy, B. B. Weksler

Research output: Contribution to journalArticle

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Abstract

Circulating platelet aggregates formed in vivo were serially measured, and platelet-aggregation thresholds were determined in vitro in 82 patients with acute cerebral ischæmia. The percentage of aggregated platelets was increased in 53 patients with completed stroke (30.9%±2.0) and in 29 patients with transient ischæmic attacks (34.1%±2.3), all studied within 10 days of the acute event. These values were higher (p<0.001) than levels of aggregated platelets in 30 patients with non-vascular neurological disease (16.8%±2.3). The percentage of aggregated platelets returned to normal 10 days to 6 wk after acute cerebral ischæmia. Aspirin and dipyridamole did not affect either the increase in or subsequent normalisation of circulating-platelet-aggregate levels in these patients. Platelet-aggregation sensitivity to adenosine diphosphate and adrenaline was also increased in patients with acute cerebral ischæmia, but this abnormality resolved during convalescence. Platelet activation is abnormal in acute cerebral ischæmia but usually returns to normal with or without anti-platelet therapy. This activation of platelets may contribute to the clinical manifestations of occlusive vascular disease.

Original languageEnglish (US)
Pages (from-to)821-824
Number of pages4
JournalThe Lancet
Volume309
Issue number8016
DOIs
StatePublished - Apr 16 1977

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Cerebrovascular Disorders
Platelet Activation
Blood Platelets
Platelet Aggregation
Dipyridamole
Vascular Diseases
Adenosine Diphosphate
Epinephrine
Aspirin
Stroke

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

PLATELET ACTIVATION IN ACUTE CEREBRAL ISCHÆMIA. Serial Measurements of Platelet Function in Cerebrovascular Disease. / Dougherty, John; Levy, D. E.; Weksler, B. B.

In: The Lancet, Vol. 309, No. 8016, 16.04.1977, p. 821-824.

Research output: Contribution to journalArticle

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