Platelet secretory mechanisms

Guy L. Reed

Research output: Contribution to journalReview article

92 Citations (Scopus)

Abstract

Platelet granule secretion or exocytosis is required for normal platelet function and plays an important role in the pathogenesis of cardiovascular diseases. Platelets secrete molecules that amplify thrombosis, induce vascular remodeling, recruit and activate cells. The platelet secretory process begins in megakaryocytes where molecules are targeted to developing granules through specific vesicle trafficking and transporter mechanisms. Secretory granules may continue to mature in the circulation after the platelet has been released from the megakaryocyte. The platelet secretory process culminates when ligands interact with specific platelet receptors to trigger exocytosis. A convergence of new insights from several different organisms has begun to illuminate the molecular mechanisms responsible for the platelet secretory process, from granule development through membrane fusion and exocytosis.

Original languageEnglish (US)
Pages (from-to)441-450
Number of pages10
JournalSeminars in Thrombosis and Hemostasis
Volume30
Issue number4
DOIs
StatePublished - Aug 1 2004

Fingerprint

Blood Platelets
Secretory Pathway
Exocytosis
Megakaryocytes
Secretory Vesicles
Membrane Fusion
Thrombosis
Cardiovascular Diseases
Ligands

All Science Journal Classification (ASJC) codes

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Platelet secretory mechanisms. / Reed, Guy L.

In: Seminars in Thrombosis and Hemostasis, Vol. 30, No. 4, 01.08.2004, p. 441-450.

Research output: Contribution to journalReview article

Reed, Guy L. / Platelet secretory mechanisms. In: Seminars in Thrombosis and Hemostasis. 2004 ; Vol. 30, No. 4. pp. 441-450.
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