Pleiotropic effect of a locus on chromosome 4 influencing alcohol drinking and emotional reactivity in rats

E. Terenina-Rigaldie, Byron Jones, P. Mormède

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A QTL search in a segregating F2 intercross between HEP (High-Ethanol Preferring line) and wistar-kyoto (WKY, a low-alcohol consuming strain) rats identified a locus on chromosome 4 linked to the consumption of a 5% alcohol solution offered as a free choice with water (Terenina-Rigaldie et al. submitted). In order to confirm and analyse the influence of this locus, F2 rats were selected according to their genotype at the markers flanking the QTL and bred in order to obtain two groups of rats homozygous HEP/HEP ('HIGH' line) or WKY/WKY ('LOW' line) at the QTL, the rest of the genome being randomly inherited from one or the other founder strain. These two groups of animals displayed large differences in emotional reactivity (open field, elevated-plus maze), sensitivity to taste reinforcers (saccharin, quinine) and alcohol consumption (either forced or as a free choice with water). These results confirm the influence of this locus on alcohol intake and emotional reactivity traits, and suggest a pleiotropic effect of the gene(s) involved. Current research aims at the identification of this (these) gene(s).

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalGenes, Brain and Behavior
Volume2
Issue number3
DOIs
StatePublished - Jun 1 2003

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Chromosomes, Human, Pair 4
Alcohol Drinking
Ethanol
Alcohols
Genetic Pleiotropy
Saccharin
Quinine
Water
Genotype
Genome
Research
Genes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

Pleiotropic effect of a locus on chromosome 4 influencing alcohol drinking and emotional reactivity in rats. / Terenina-Rigaldie, E.; Jones, Byron; Mormède, P.

In: Genes, Brain and Behavior, Vol. 2, No. 3, 01.06.2003, p. 125-131.

Research output: Contribution to journalArticle

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