Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation

John T. Lovell, Thomas E. Juenger, Scott D. Michaels, Jesse R. Lasky, Alexander Platt, James H. Richards, Xuhong Yu, Hsien M. Easlon, Saunak Sen, John K. Mckay

Research output: Contribution to journalArticle

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Abstract

An evolutionary response to selection requires genetic variation; however, even if it exists, then the genetic details of the variation can constrain adaptation. In the simplest case, unlinked loci and uncorrelated phenotypes respond directly to multivariate selection and permit unrestricted paths to adaptive peaks. By contrast, 'antagonistic' pleiotropic loci may constrain adaptation by affecting variation of many traits and limiting the direction of trait correlations to vectors that are not favoured by selection. However, certain pleiotropic configurations may improve the conditions for adaptive evolution. Here, we present evidence that the Arabidopsis thaliana gene FRI (FRIGIDA) exhibits 'adaptive' pleiotropy, producing trait correlations along an axis that results in two adaptive strategies. Derived, low expression FRI alleles confer a 'drought escape' strategy owing to fast growth, low water use efficiency and early flowering. By contrast, a dehydration avoidance strategy is conferred by the ancestral phenotype of late flowering, slow growth and efficient water use during photosynthesis. The dehydration avoidant phenotype was recovered when genotypes with null FRI alleles were transformed with functional alleles. Our findings indicate that the well-documented effects of FRI on phenology result from differences in physiology, not only a simple developmental switch.

Original languageEnglish (US)
Article number20130174
JournalProceedings of the Royal Society B: Biological Sciences
Volume280
Issue number1763
DOIs
StatePublished - Jul 22 2013

Fingerprint

pleiotropy
Dehydration
phenotype
allele
Alleles
desiccation (plant physiology)
Phenotype
dehydration
flowering
Photosynthesis
Water
Drought
Physiology
alleles
genetic variation
loci
null alleles
Genes
Droughts
Switches

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

Lovell, J. T., Juenger, T. E., Michaels, S. D., Lasky, J. R., Platt, A., Richards, J. H., ... Mckay, J. K. (2013). Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. Proceedings of the Royal Society B: Biological Sciences, 280(1763), [20130174]. https://doi.org/10.1098/rspb.2013.1043

Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. / Lovell, John T.; Juenger, Thomas E.; Michaels, Scott D.; Lasky, Jesse R.; Platt, Alexander; Richards, James H.; Yu, Xuhong; Easlon, Hsien M.; Sen, Saunak; Mckay, John K.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 280, No. 1763, 20130174, 22.07.2013.

Research output: Contribution to journalArticle

Lovell, JT, Juenger, TE, Michaels, SD, Lasky, JR, Platt, A, Richards, JH, Yu, X, Easlon, HM, Sen, S & Mckay, JK 2013, 'Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation', Proceedings of the Royal Society B: Biological Sciences, vol. 280, no. 1763, 20130174. https://doi.org/10.1098/rspb.2013.1043
Lovell JT, Juenger TE, Michaels SD, Lasky JR, Platt A, Richards JH et al. Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. Proceedings of the Royal Society B: Biological Sciences. 2013 Jul 22;280(1763). 20130174. https://doi.org/10.1098/rspb.2013.1043
Lovell, John T. ; Juenger, Thomas E. ; Michaels, Scott D. ; Lasky, Jesse R. ; Platt, Alexander ; Richards, James H. ; Yu, Xuhong ; Easlon, Hsien M. ; Sen, Saunak ; Mckay, John K. / Pleiotropy of FRIGIDA enhances the potential for multivariate adaptation. In: Proceedings of the Royal Society B: Biological Sciences. 2013 ; Vol. 280, No. 1763.
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