Pneumocystis carinii Serologic Study in Pediatric Acquired Immunodeficiency Syndrome

Linda Pifer, Diane R. Woods, Carol C. Edwards, Rebecca E. Joyner, Frank J. Anderson, Kris Arheart

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Pneumocystis carinii antigen and IgG antibody profiles were prepared on 17 pediatric patients with acquired immunodeficiency syndrome (AIDS) with pneumonia who were examined by a variety of invasive methods for P carinii organisms. Overall, the accuracy of the antigen assay in invasively examined pediatric patients with AIDS with pneumonia was 94% (sensitivity, 100%; specificity, 90%), as antigen and invasive test results agreed in 16 of 17 patients. No statistically significant differences in IgG titer were observed between controls and patients invasively examined for P carinii, whether the organism was observed in the specimen or not. Since 38% of all serum samples referred were derived from “blood-borne” cases of AIDS, including patients who contracted AIDS as a result of both transfusion and hemophilia A, this suggests that P carinii pneumonia or P carinii pneumonia—like pneumonias may be more common in these individuals.

Original languageEnglish (US)
Pages (from-to)36-39
Number of pages4
JournalAmerican Journal of Diseases of Children
Volume142
Issue number1
DOIs
StatePublished - Jan 1 1988

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Pneumocystis carinii
Acquired Immunodeficiency Syndrome
Pediatrics
Pneumonia
Antigens
Immunoglobulin G
Hemophilia A
Antibodies
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Pneumocystis carinii Serologic Study in Pediatric Acquired Immunodeficiency Syndrome. / Pifer, Linda; Woods, Diane R.; Edwards, Carol C.; Joyner, Rebecca E.; Anderson, Frank J.; Arheart, Kris.

In: American Journal of Diseases of Children, Vol. 142, No. 1, 01.01.1988, p. 36-39.

Research output: Contribution to journalArticle

Pifer, Linda ; Woods, Diane R. ; Edwards, Carol C. ; Joyner, Rebecca E. ; Anderson, Frank J. ; Arheart, Kris. / Pneumocystis carinii Serologic Study in Pediatric Acquired Immunodeficiency Syndrome. In: American Journal of Diseases of Children. 1988 ; Vol. 142, No. 1. pp. 36-39.
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