Polyester particles for curcumin delivery

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Curcumin is a phenolic molecule extracted from turmeric and is prevalently used in Asian cuisine. This molecule has also shown great pharmacological activities. The pleiotropic property of curcumin enables it to act on multiple targets and as a promising therapeutic agent for various diseases. However, the treatment paradigm of curcumin in the clinical setting is not well established because of its low solubility, poor adsorption, low bioavailability, nonlinear pharmacokinetics, extensive metabolism, and degradation/ secretion. Particle-mediated delivery of curcumin can address such shortcomings and enhance the therapeutic activity of curcumin. Particle technology aimed at preferential accumulation of curcumin at the disease site, thereby reducing adverse side effects, makes curcumin ideal as an efficient delivery strategy. Therefore, this chapter discusses polyester particles for curcumin delivery based on structurally varied delivery systems, which are aimed at increasing bioavailability and biological effects. This chapter also discloses possible translational recommendations for polyester based curcumin particles for developing alternative clinical formulation(s) for therapeutic applications.

Original languageEnglish (US)
Title of host publicationHandbook of Polyester Drug Delivery Systems
PublisherPan Stanford Publishing Pte. Ltd.
Pages651-673
Number of pages23
ISBN (Electronic)9789814669665
ISBN (Print)9789814669658
DOIs
StatePublished - Jun 9 2016

Fingerprint

Curcumin
Polyesters
Molecules
Pharmacokinetics
Metabolism
Solubility
Adsorption
Degradation
Biological Availability
Curcuma
Therapeutics
Pharmacology
Technology

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Engineering(all)
  • Materials Science(all)

Cite this

Yallapu, M., Jaggi, M., & Chauhan, S. (2016). Polyester particles for curcumin delivery. In Handbook of Polyester Drug Delivery Systems (pp. 651-673). Pan Stanford Publishing Pte. Ltd.. https://doi.org/10.4032/9789814669665

Polyester particles for curcumin delivery. / Yallapu, Murali; Jaggi, Meena; Chauhan, Subhash.

Handbook of Polyester Drug Delivery Systems. Pan Stanford Publishing Pte. Ltd., 2016. p. 651-673.

Research output: Chapter in Book/Report/Conference proceedingChapter

Yallapu, M, Jaggi, M & Chauhan, S 2016, Polyester particles for curcumin delivery. in Handbook of Polyester Drug Delivery Systems. Pan Stanford Publishing Pte. Ltd., pp. 651-673. https://doi.org/10.4032/9789814669665
Yallapu M, Jaggi M, Chauhan S. Polyester particles for curcumin delivery. In Handbook of Polyester Drug Delivery Systems. Pan Stanford Publishing Pte. Ltd. 2016. p. 651-673 https://doi.org/10.4032/9789814669665
Yallapu, Murali ; Jaggi, Meena ; Chauhan, Subhash. / Polyester particles for curcumin delivery. Handbook of Polyester Drug Delivery Systems. Pan Stanford Publishing Pte. Ltd., 2016. pp. 651-673
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