Polygenic determination of quinine aversion among mice

John Boughter, D. B. Harder, C. G. Capeless, G. Whitney

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

There are substantial differences among inbred mouse strains in avoidance of quinine solutions in two-bottle preference tests. x A Mendelian cross-breeding experiment was conducted to test the hypothesis that a single locus Qui has a major influence on quinine aversion. Inbred strains C57B1/6J (B6, avoider) and C3HeB/FeJ (C3, indifferent) were progenitors of two segregating generations. Phenotypic ratios for 100 μM and 30 μM quinine sulfate (QSO4) in these generations were not consistent with ratios expected for a single gene. Frequency distributions for individual preference ratios were more characteristic of a polygenic trait. An outbred strain (CFW/Crl) which displays segregation for the Soa locus was tested for both QSO4 and sucrose octa-acetate (SOA) avoidance. Correlated avoidance patterns for the two bitter compounds were found in these mice. A Soa effect might not have been seen in the C3.B6 cross because both strains are relatively poor SOA avoiders. A second Mendelian cross was made between strains C3 and SWR/J (SW, SOA and QSO4 avoider). One segregating generation was tested with both compounds. In these mice, as in the CFW population, QSO4 aversion was correlated with SOA aversion. These results suggest that quinine aversion is polygenic, that there is a relationship between SOA sensitivity and quinine sensitivity, and that this association may be the result of variation at the Soa locus.

Original languageEnglish (US)
Pages (from-to)427-434
Number of pages8
JournalChemical Senses
Volume17
Issue number4
DOIs
StatePublished - Aug 1 1992
Externally publishedYes

Fingerprint

Quinine
Multifactorial Inheritance
Inbred Strains Mice
Breeding
sucrose octaacetate
Population
Genes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Sensory Systems
  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Polygenic determination of quinine aversion among mice. / Boughter, John; Harder, D. B.; Capeless, C. G.; Whitney, G.

In: Chemical Senses, Vol. 17, No. 4, 01.08.1992, p. 427-434.

Research output: Contribution to journalArticle

Boughter, J, Harder, DB, Capeless, CG & Whitney, G 1992, 'Polygenic determination of quinine aversion among mice', Chemical Senses, vol. 17, no. 4, pp. 427-434. https://doi.org/10.1093/chemse/17.4.427
Boughter, John ; Harder, D. B. ; Capeless, C. G. ; Whitney, G. / Polygenic determination of quinine aversion among mice. In: Chemical Senses. 1992 ; Vol. 17, No. 4. pp. 427-434.
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