Polymer-supported (2,6-dichloro-4-alkoxyphenyl)(2,4-dichlorophenyl) methanol

A new linker for solid-phase organic synthesis

Michio Kurosu, Kallolmay Biswas, Dean C. Crick

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

(Chemical Equation Presented) An acid and base stable hydroxytetrachlorodiphenylmethyl (HTPM) linker is developed for polymer-supported organic synthesis. The linkers reported here are utilized for loading carboxylic acids, amines, alcohols, and phenols, and are stable to Brønsted and Lewis acids, Brønsted bases, and a wide variety of nucleophiles. However, the HTPM linkers can conveniently be cleaved by the solvolytic displacement reactions with 20% TFA.

Original languageEnglish (US)
Pages (from-to)1141-1144
Number of pages4
JournalOrganic letters
Volume9
Issue number6
DOIs
StatePublished - Mar 15 2007
Externally publishedYes

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Synthetic Chemistry Techniques
Solid-Phase Synthesis Techniques
Methanol
solid phases
Polymers
methyl alcohol
Lewis Acids
Nucleophiles
acids
Phenols
nucleophiles
polymers
synthesis
Carboxylic Acids
carboxylic acids
phenols
Amines
amines
alcohols
Alcohols

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

Cite this

Polymer-supported (2,6-dichloro-4-alkoxyphenyl)(2,4-dichlorophenyl) methanol : A new linker for solid-phase organic synthesis. / Kurosu, Michio; Biswas, Kallolmay; Crick, Dean C.

In: Organic letters, Vol. 9, No. 6, 15.03.2007, p. 1141-1144.

Research output: Contribution to journalArticle

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AU - Crick, Dean C.

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